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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0019704,
umls-concept:C0030957,
umls-concept:C0086418,
umls-concept:C0205460,
umls-concept:C0220781,
umls-concept:C0441655,
umls-concept:C1704675,
umls-concept:C1707689,
umls-concept:C1883254,
umls-concept:C1999216
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|
pubmed:issue |
9
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|
pubmed:dateCreated |
2000-11-15
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pubmed:abstractText |
Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of Tat protein with the transactivation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5'-end of all HIV mRNAs. A number of cyclic peptides are known to possess antibiotic activity and increased biological stability. Here we report the design, synthesis, and biological activity of a cyclic peptide (2), which inhibits transcriptional activation by Tat protein in human cells with an IC50 of approximately 40 nM. Cyclic peptides that can target specific RNA structures provide a new class of small molecules that can be used to control cellular processes involving RNA-protein interactions in vivo.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
|
|
pubmed:volume |
10
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
971-4
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10853671-Anti-HIV Agents,
pubmed-meshheading:10853671-Cells, Cultured,
pubmed-meshheading:10853671-Drug Design,
pubmed-meshheading:10853671-Gene Expression Regulation, Viral,
pubmed-meshheading:10853671-Gene Products, tat,
pubmed-meshheading:10853671-HIV-1,
pubmed-meshheading:10853671-HeLa Cells,
pubmed-meshheading:10853671-Humans,
pubmed-meshheading:10853671-Ligands,
pubmed-meshheading:10853671-Peptides, Cyclic,
pubmed-meshheading:10853671-RNA, Viral,
pubmed-meshheading:10853671-Transcriptional Activation,
pubmed-meshheading:10853671-tat Gene Products, Human Immunodeficiency Virus
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|
pubmed:year |
2000
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|
pubmed:articleTitle |
Design, synthesis, and biological activity of a cyclic peptide: an inhibitor of HIV-1 tat-TAR interactions in human cells.
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|
pubmed:affiliation |
Department of Pharmacology, Robert Wood Johnson Medical School, and Molecular Biosciences Graduate Program at Rutgers State University, Piscataway, NJ 08854, USA.
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pubmed:publicationType |
Journal Article
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