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10853668
Source:
http://linkedlifedata.com/resource/pubmed/id/10853668
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0205460
,
umls-concept:C0220781
,
umls-concept:C0441655
,
umls-concept:C1533691
,
umls-concept:C1707689
,
umls-concept:C1883254
,
umls-concept:C2267054
pubmed:issue
9
pubmed:dateCreated
2000-11-15
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/PDB/1QB9
pubmed:abstractText
A series of indole and carbazole based inhibitors of factor Xa (FXa) has been investigated. The most potent compound inhibits FXa with a Ki of 0.2 nM and has 900- and 750-fold selectivity over thrombin and trypsin, respectively.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amidines
,
http://linkedlifedata.com/resource/pubmed/chemical/Anticoagulants
,
http://linkedlifedata.com/resource/pubmed/chemical/Carbazoles
,
http://linkedlifedata.com/resource/pubmed/chemical/Factor Xa
,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles
,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines
,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombin
,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/ZK 807834
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0960-894X
pubmed:author
pubmed-author:ArnaizD ODO
,
pubmed-author:KoovakkatS KSK
,
pubmed-author:LiangAA
,
pubmed-author:ShawK JKJ
,
pubmed-author:TrinkAA
,
pubmed-author:WitlowMM
,
pubmed-author:ZhaoZZ
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
957-61
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10853668-Amidines
,
pubmed-meshheading:10853668-Anticoagulants
,
pubmed-meshheading:10853668-Carbazoles
,
pubmed-meshheading:10853668-Chemistry, Physical
,
pubmed-meshheading:10853668-Crystallography, X-Ray
,
pubmed-meshheading:10853668-Factor Xa
,
pubmed-meshheading:10853668-Humans
,
pubmed-meshheading:10853668-Indoles
,
pubmed-meshheading:10853668-Models, Molecular
,
pubmed-meshheading:10853668-Molecular Conformation
,
pubmed-meshheading:10853668-Physicochemical Phenomena
,
pubmed-meshheading:10853668-Pyridines
,
pubmed-meshheading:10853668-Structure-Activity Relationship
,
pubmed-meshheading:10853668-Thrombin
,
pubmed-meshheading:10853668-Trypsin Inhibitors
pubmed:year
2000
pubmed:articleTitle
Design, synthesis, and in vitro biological activity of indole-based factor Xa inhibitors.
pubmed:affiliation
Discovery Research, Berlex Biosciences, Richmond, CA 94804, USA. damian_arnaiz@berlex.com
pubmed:publicationType
Journal Article