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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2000-11-15
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pubmed:abstractText |
5,7-Diphenyl-pyrrolo[2,3d]pyrimidines represent a new class of highly potent inhibitors of the tyrosine kinase c-Src (IC50 < 50 nM) with specificity against a panel of different tyrosine kinases. The substitution pattern on the two phenyl rings determines potency and specificity and provides a means to modulate cellular activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
945-9
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:10853665-Animals,
pubmed-meshheading:10853665-Blotting, Western,
pubmed-meshheading:10853665-Chickens,
pubmed-meshheading:10853665-Enzyme Inhibitors,
pubmed-meshheading:10853665-Models, Molecular,
pubmed-meshheading:10853665-Phosphorylation,
pubmed-meshheading:10853665-Protein-Tyrosine Kinases,
pubmed-meshheading:10853665-Pyrimidines,
pubmed-meshheading:10853665-Pyrroles,
pubmed-meshheading:10853665-Structure-Activity Relationship,
pubmed-meshheading:10853665-Substrate Specificity
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pubmed:year |
2000
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pubmed:articleTitle |
Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src.
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pubmed:affiliation |
Novartis Pharma AG, Therapeutic Areas Arthritis & Bone Metabolism, Basel, Switzerland. martin.missbach@pharma.novartis.com
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pubmed:publicationType |
Journal Article
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