Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-11-7
pubmed:abstractText
Lyme borreliosis is a multisystem disorder caused by the spirochete Borrelia burgdorferi that is transmitted to humans by the tick Ixodes dammini. The immune response against the 31 kDa OspA, which is one of the most abundant B. burgdorferi proteins, appears to be critical in preventing infection and tissue inflammation. Detailed knowledge of the immunological and molecular characteristics of the OspA protein is important for the development of reliable diagnostic assays. In this study, we characterized a new conformational epitope present within the middle part of B. burgdorferi OspA. Our approach used enzymatic proteolyses of the immune complex followed by mass spectrometric identification of the peptides bound to the antibody. It appears to be one of the first reports on the characterization of a discontinuous epitope using mass spectrometry.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-10222350, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-10330909, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-10418202, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-10480752, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-10600340, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-1172191, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-1279368, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-1370170, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-1563773, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-1602994, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-1696028, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-1702219, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-1716290, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-1829104, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-2037351, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-2136237, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-2237407, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-2318538, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-2339119, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-2411827, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-2461135, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-2578661, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-2668764, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-2685927, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-3343329, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-3531237, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-388439, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-476090, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-7043737, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-7528478, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-7530543, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-7691186, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-7768602, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-7890394, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-825377, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-8633009, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-8683115, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-8703433, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-8961925, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-9108020, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-9548539, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-9679595, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-9680475, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-9829633, http://linkedlifedata.com/resource/pubmed/commentcorrection/10850810-9879358
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface, http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Outer Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Vaccines, http://linkedlifedata.com/resource/pubmed/chemical/Cyanogen Bromide, http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, http://linkedlifedata.com/resource/pubmed/chemical/Glycine, http://linkedlifedata.com/resource/pubmed/chemical/Ions, http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Lyme Disease Vaccines, http://linkedlifedata.com/resource/pubmed/chemical/OspA protein, http://linkedlifedata.com/resource/pubmed/chemical/Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0961-8368
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1002-10
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...