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rdf:type |
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lifeskim:mentions |
umls-concept:C0040715,
umls-concept:C0049579,
umls-concept:C0205314,
umls-concept:C0231335,
umls-concept:C0238463,
umls-concept:C0376315,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C0679622,
umls-concept:C0694890,
umls-concept:C1522702,
umls-concept:C1549863,
umls-concept:C1706214
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pubmed:issue |
11
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pubmed:dateCreated |
2000-6-30
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pubmed:abstractText |
Evaluation of 20 cases of radiation-induced childhood papillary thyroid carcinoma using fluorescence in situ hybridization demonstrated the presence of clonal translocations affecting the RET locus. Semiquantitative reverse transcription-PCR indicated overexpression of the RET tyrosine kinase (TK) domain in four cases. In two cases, the RET rearrangements PTC6 and PTC7 were identified and assigned to balanced translocations t(7;10)(q32;q11.2) and t(1;10)(p13;q11.2), respectively. In one case with a balanced translocation t(10;14)(q11.2;q22.1), 5' rapid amplification of cDNA ends revealed a novel type of RET oncogenic activation (PTC8), arising from a fusion of the 5' part of the kinectin (KTN1) gene to the TK domain of the RET gene. The presence of coiled-coil domains in the resulting ktn1/ret fusion protein suggests ligand-independent dimerization and thus constitutive activation of the ret TK domain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/KTN1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ret,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Ret oncogene protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2786-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10850414-Base Sequence,
pubmed-meshheading:10850414-Carcinoma, Papillary,
pubmed-meshheading:10850414-Cells, Cultured,
pubmed-meshheading:10850414-Chromosomes, Artificial, Yeast,
pubmed-meshheading:10850414-Chromosomes, Human, Pair 10,
pubmed-meshheading:10850414-Chromosomes, Human, Pair 14,
pubmed-meshheading:10850414-DNA Mutational Analysis,
pubmed-meshheading:10850414-Drosophila Proteins,
pubmed-meshheading:10850414-Humans,
pubmed-meshheading:10850414-In Situ Hybridization, Fluorescence,
pubmed-meshheading:10850414-Membrane Proteins,
pubmed-meshheading:10850414-Molecular Sequence Data,
pubmed-meshheading:10850414-Neoplasms, Radiation-Induced,
pubmed-meshheading:10850414-Power Plants,
pubmed-meshheading:10850414-Protein-Tyrosine Kinases,
pubmed-meshheading:10850414-Proto-Oncogene Proteins,
pubmed-meshheading:10850414-Proto-Oncogene Proteins c-ret,
pubmed-meshheading:10850414-RNA, Messenger,
pubmed-meshheading:10850414-Radioactive Hazard Release,
pubmed-meshheading:10850414-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:10850414-Receptors, Cell Surface,
pubmed-meshheading:10850414-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10850414-Thyroid Gland,
pubmed-meshheading:10850414-Thyroid Neoplasms,
pubmed-meshheading:10850414-Translocation, Genetic,
pubmed-meshheading:10850414-Ukraine
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pubmed:year |
2000
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pubmed:articleTitle |
Translocation t(10;14)(q11.2:q22.1) fusing the kinetin to the RET gene creates a novel rearranged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma.
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pubmed:affiliation |
Institute of Radiation Biology, Ludwig Maximilians University, München, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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