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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1976-8-23
|
| pubmed:abstractText |
Blastogenic transformation of peripheral lymphocytes with phytohemagglutinin (PHA), conconavalin A (Con A), and pokeweed mitogen (PWM) was studied in 29 patients with rheumatoid arthritis (RA). The PHA response was depressed in a subgroup of RA patients with erosive disease. The Con A response was also depressed and paralleled the PHA response. The PWM response was not depressed. These results lend support to the hypothesis of a functional defect of cellular immunity in RA. It was shown that lymphocyte responsiveness to a single mitogen concentration is not an adequate assessment of the overall responsiveness of the lymphocytes tested.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0004-3591
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
509-15
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1084749-Adult,
pubmed-meshheading:1084749-Antibodies, Antinuclear,
pubmed-meshheading:1084749-Arthritis, Rheumatoid,
pubmed-meshheading:1084749-Concanavalin A,
pubmed-meshheading:1084749-Dose-Response Relationship, Drug,
pubmed-meshheading:1084749-Humans,
pubmed-meshheading:1084749-Lectins,
pubmed-meshheading:1084749-Lymphocyte Activation,
pubmed-meshheading:1084749-Lymphocytes,
pubmed-meshheading:1084749-Middle Aged,
pubmed-meshheading:1084749-Regression Analysis,
pubmed-meshheading:1084749-Tuberculosis
|
| pubmed:articleTitle |
Altered lymphocyte reactivity in rheumatoid arthritis.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|