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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-8-29
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pubmed:abstractText |
Putative gender differences in opiate cardiovascular effects were evaluated in spinal rats. After a 4-h exposure to a single dose of morphine (30 mg/kg, i.v.), abstinence was precipitated by naloxone (0.03-3 mg/kg, i.v.). Morphine produced a long-lasting bradycardia and a transient increase in arterial pressure that was similar in both genders. Thereafter, blood pressure decreased both in males and females. Naloxone precipitated a similar dose-dependent heart rate increase in both sexes and a gender-dependent increase in blood pressure. This sex difference appeared in the shape of the response. Prazosin (0.2 mg/kg), prior to naloxone, reduced the pressor response in all animals, suggesting a similar participation of the noradrenergic system in both genders. The present results extend to acute dependence the notion of a sex-dependent differential effect of morphine. The need to consider gender as a factor when studying the effects of opioids is highlighted.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
397
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10844106-Adrenergic alpha-Antagonists,
pubmed-meshheading:10844106-Analgesics, Opioid,
pubmed-meshheading:10844106-Animals,
pubmed-meshheading:10844106-Blood Pressure,
pubmed-meshheading:10844106-Cardiovascular System,
pubmed-meshheading:10844106-Dose-Response Relationship, Drug,
pubmed-meshheading:10844106-Female,
pubmed-meshheading:10844106-Heart Rate,
pubmed-meshheading:10844106-Male,
pubmed-meshheading:10844106-Morphine,
pubmed-meshheading:10844106-Morphine Dependence,
pubmed-meshheading:10844106-Naloxone,
pubmed-meshheading:10844106-Narcotic Antagonists,
pubmed-meshheading:10844106-Prazosin,
pubmed-meshheading:10844106-Rats,
pubmed-meshheading:10844106-Rats, Wistar,
pubmed-meshheading:10844106-Sex Factors,
pubmed-meshheading:10844106-Spinal Cord
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pubmed:year |
2000
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pubmed:articleTitle |
Gender differences in the cardiovascular responses to morphine and naloxone in spinal rats.
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pubmed:affiliation |
Departamento de Farmacología y Toxicología, Cinvestav, IPN, Apartado Postal 22026, 14000, D.F., Mexico City, Mexico. jcmolcruz@compuserve.com.mx
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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