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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1976-9-1
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pubmed:abstractText |
The in vitro T-cell proliferation induced by penicilloylated bovine IgG (BPO-BGG) in sensitized strain 2 and strain 13 guinea pigs could be specifically blocked by strain-specific antisera presumably directed against cell membrane-associated immunoglobulin idiotypes. The anti-idiotypic antisera were prepared in strain 2 and strain 13 guinea pigs against immunoadsorbent purified anti-BPO-BGG antibodies which had been raised in strain 2 and strain 13 animals. Strain 13 antistrain 13 anti-BPO-BGG (a strain 13 BPO-BGG) suppressed the in vitro BPO-BGG response of cells from immunized strain 13 animals but did not inhibit the response of cells from immune strain 2 animals. Conversely, the corresponding antiserum raised in a strain 2 combination (a strain 2 BPO-BGG) only inhibited the in vitro BPO-BGG response of strain 2 cells. Furthermore, the inhibitory activity of the antisera could only be absorbed by immune cells from the syngeneic strain. The activity of the a strain 13 BPO-BGG serum was highly specific; the inhibitory activity could only be absorbed by BPO-BGG-sensitive strain 13 cells. The inhibitory activity of the anti-idiotypic sera was predominantly associated with the 19S fraction. The data suggest that immune cells and in particular T lymphocytes from strain 2 and strain 13 guinea pigs possess strain-specific recognition structures from BPO-BGG with the same idiotypes as the corresponding strain-specific immunoglobulins. Furthermore, the production of such inhibitory anti-idiotypic sera was restricted to syngeneic combinations, which suggests a potential role of autoanti-idiotypic antibodies in the regulation of the immune response. The anti-idiotypic antisera used here are apparently directed against gene products not associated with the strain 2 or strain 13 major histocompatibility complex.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-1102116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-11993322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-11993330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-11993340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-14030666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-14450081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-4100380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-4107130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-4108380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-4130243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-4177521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-4403565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-4413687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-4546826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-4623607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-46887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-4717931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-50001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-50400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-5112203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-5126639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084404-53257
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
226-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1084404-Animals,
pubmed-meshheading:1084404-Antigen-Antibody Reactions,
pubmed-meshheading:1084404-Genes,
pubmed-meshheading:1084404-Histocompatibility Antigens,
pubmed-meshheading:1084404-Immunoglobulin Allotypes,
pubmed-meshheading:1084404-Immunoglobulin G,
pubmed-meshheading:1084404-Lymphocyte Activation,
pubmed-meshheading:1084404-Peptides,
pubmed-meshheading:1084404-Receptors, Antigen, B-Cell,
pubmed-meshheading:1084404-T-Lymphocytes
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pubmed:year |
1976
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pubmed:articleTitle |
Histocompatibility antigens and genetic control of the immune response in guinea pigs. III. Specific inhibition of antigen-induced lymphocyte proliferation by strain-specific anti-idiotypic antibodies.
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pubmed:publicationType |
Journal Article
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