Linked Life Data

10844041

Source:http://linkedlifedata.com/resource/pubmed/id/10844041

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2000-6-30
pubmed:abstractText
The chemical properties that determine the distribution of the electro-olfactogram were studied after exposure of a large area of the rat olfactory epithelium. Multiple electrodes were placed along the rostral border of endoturbinate IV on the midline of the nasal cavity. This array of electrodes spanned a region containing the four receptor gene expression zones described for the rat. The response to a series of odorants containing only carbon, hydrogen, and oxygen was strongly related to electrode position. For most hydrocarbons, the responses were progressively larger toward the ventral epithelium. The only exceptions were aromatic hydrocarbons, which evoked nearly equal response sizes across the epithelium. Ketones and aldehydes evoked relatively larger dorsal responses than did hydrocarbons with similar structures. Aromatic ketones and aldehydes evoked systematically larger responses from the dorsal part of the epithelium. The response profiles for most odorants were well described by a linear fit to the electrode position along the dorsal-ventral position on the epithelium. However, a few bicyclic odorants and carboxylic acids evoked significantly nonlinear profiles. It is concluded that there is a systematic distribution of odorant sensitivity across this part of the epithelium and that this sensitivity is related to general chemical properties. Other evidence suggests that these properties extend to other parts of the epithelium. This spatial sensitivity of the epithelium to odorants probably contributes to olfactory coding in parallel with the convergence of axons from olfactory sensory neurons expressing the same receptor type.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4721-31
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Chemical determinants of the rat electro-olfactogram.
pubmed:affiliation
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322-3030, USA. JohnS@cellbio.emory.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.