Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1976-9-1
pubmed:abstractText
Cultures of peritoneal exudate cells rich in macrophages were studied for the secretion of lymphostimulatory molecules. Two conditions produced increased secretion: (a) addition to the cultures of various agents that readily interacted with macrophages, such as latex particles, antibody-coated red cells, endotoxin, Listeria organisms, or Be salt; or (b) addition of activated lymphocytes. In the first case the increased activity was found during the first 24 or 48 h after uptake of the stimuli. Increased activity was found in normal or peptone-stimulated macrophages but not in macrophages after injection of endotoxin or thioglycollate. The addition of T lymphocytes from Listeria-infected mice to macrophage cultures increased greatly the activities. This increase was also produced by addition to antigen-primed T cells together with antigen. The lymphocytes by themselves did not secrete active factors. The lymphostimulatory activities were tested on thymocyte DNA synthesis and on antibody formation in vitro. The latter assay was done on spleen cells from immunized mice where one striking effect was the stimulation of differentiation to antibody-secreting cells. Some dissociation of both activities (thymocyte DNA synthesis and B-cell differentiation) was observed with selected culture fluids.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-1078603, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-1081996, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-1097572, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-167095, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-167096, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-4128440, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-4326352, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-4427092, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-4587740, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-4606516, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-4816302, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-5033417, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-5103320, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-5523579, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-5796861, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-6028491, http://linkedlifedata.com/resource/pubmed/commentcorrection/1084402-6034749
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-66
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
The modulation of lymphocyte functions by molecules secreted by macrophages. II. Conditions leading to increased secretion.
pubmed:publicationType
Journal Article