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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2000-8-23
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pubmed:abstractText |
Interleukin 6 (IL-6) is a cytokine that acts on a wide range of tissues influencing cell growth and differentiation. Here we show that IL-6 plays a role in the early vascular development (vasculogenesis) in the central nervous system (CNS). We report that IL-6 induces the proliferation of brain microvascular endothelial cells in vitro. Furthermore, IL-6 significantly accelerates the formation of tube-like structures by these cells in Matrigel basement matrix. Moreover, IL-6 mRNA is expressed in vivo in two physiological conditions in which vascularization in the CNS is important: (1) during normal brain development, (2) during the healing process of a traumatic brain injury. Expression of IL-6 mRNA coincides with the expression of vascular endothelial growth factor (VEGF) mRNA in the developing brain with decreasing expression following birth. However, IL-6 mRNA can be detected in the healing adult murine brain tissue by in situ hybridization coinciding with the period of intense tissue reorganization. The transient upregulation of IL-6 mRNA during normal brain development and at brain injury site and the effect of IL-6 on in vitro vasculogenesis suggest that IL-6 may play a role in normal physiology of vascularization in the CNS.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1043-4666
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
655-65
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10843741-Aging,
pubmed-meshheading:10843741-Animals,
pubmed-meshheading:10843741-Basement Membrane,
pubmed-meshheading:10843741-Brain,
pubmed-meshheading:10843741-Cells, Cultured,
pubmed-meshheading:10843741-Cerebrovascular Circulation,
pubmed-meshheading:10843741-Collagen,
pubmed-meshheading:10843741-Drug Combinations,
pubmed-meshheading:10843741-Embryonic and Fetal Development,
pubmed-meshheading:10843741-Endothelial Growth Factors,
pubmed-meshheading:10843741-Endothelium, Vascular,
pubmed-meshheading:10843741-Gene Expression Regulation, Developmental,
pubmed-meshheading:10843741-Interleukin-6,
pubmed-meshheading:10843741-Laminin,
pubmed-meshheading:10843741-Lymphokines,
pubmed-meshheading:10843741-Mice,
pubmed-meshheading:10843741-Mice, Inbred BALB C,
pubmed-meshheading:10843741-Microcirculation,
pubmed-meshheading:10843741-Neovascularization, Physiologic,
pubmed-meshheading:10843741-Proteoglycans,
pubmed-meshheading:10843741-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10843741-Transcription, Genetic,
pubmed-meshheading:10843741-Vascular Endothelial Growth Factor A,
pubmed-meshheading:10843741-Vascular Endothelial Growth Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Interleukin 6 promotes vasculogenesis of murine brain microvessel endothelial cells.
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pubmed:affiliation |
Department of Neurology, University of Wisconsin, Madison, WI, 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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