Source:http://linkedlifedata.com/resource/pubmed/id/10843683
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2000-7-20
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| pubmed:abstractText |
Many natural viral and bacterial pathogens activate B cells independently of Th cells (TI Ags). This study analyzed the characteristics of the activation of B cells after immunization with various forms of viral Ags using different immunization routes and found a decreasing dependence on T help with increasing amounts of Ag recruited to the spleen. Repetitive antigenic structure facilitated TI B cell responses if Ag was present in lymphoid organs. These results suggest that 1) Ag dose and localization in secondary lymphoid organs are the key for B cell activation in the absence of T help; 2) early TI Ab responses are crucial to protect against systemically spreading acute cytopathic infectious agents; and 3) there may be new rationales for improved vaccine design.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
164
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6296-302
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10843683-Animals,
pubmed-meshheading:10843683-Antibodies, Viral,
pubmed-meshheading:10843683-Antigens, T-Independent,
pubmed-meshheading:10843683-Antigens, Viral,
pubmed-meshheading:10843683-Dose-Response Relationship, Immunologic,
pubmed-meshheading:10843683-Immunohistochemistry,
pubmed-meshheading:10843683-Injections, Intravenous,
pubmed-meshheading:10843683-Injections, Subcutaneous,
pubmed-meshheading:10843683-Lymphoid Tissue,
pubmed-meshheading:10843683-Mice,
pubmed-meshheading:10843683-Mice, Inbred BALB C,
pubmed-meshheading:10843683-Mice, Inbred C57BL,
pubmed-meshheading:10843683-Mice, Inbred CBA,
pubmed-meshheading:10843683-Mice, Nude,
pubmed-meshheading:10843683-Rhabdoviridae Infections,
pubmed-meshheading:10843683-Splenectomy,
pubmed-meshheading:10843683-Structure-Activity Relationship,
pubmed-meshheading:10843683-Vesicular stomatitis Indiana virus,
pubmed-meshheading:10843683-Viral Vaccines
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Correlation of T cell independence of antibody responses with antigen dose reaching secondary lymphoid organs: implications for splenectomized patients and vaccine design.
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| pubmed:affiliation |
Institute for Experimental Immunology, University Hospital, Zurich, Switzerland. adrian.ochsenbein@insel.ch
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|