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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-6-20
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160732,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160733,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160734,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160735,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160736,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160737,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160738,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160739,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160740,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160741,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160742,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160743,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160744,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160745,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160746,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160747,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160748,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160749,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160750,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160751,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160752,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160753,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF160754
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pubmed:abstractText |
Heroin users from Guangxi province, a southern province of China that borders Vietnam in the south and Yunnan province in China in the west, were studied for prevalence and risk factors for HIV-1 infection. Viral env sequences from HIV-1-positive individuals were also determined for subtypes of HIV-1. The overall HIV prevalence among 227 heroin users was 40%. Most had used drugs for < or = 3 years. Sharing of injection equipment and unprotected sex were significantly associated with HIV-1 infection. Subtypes C and E HIV-1 were detected in infected heroin users and were sharply segregated in two geographic locations: only subtype C was found in a border city with Yunnan province, whereas only subtype E was found in a city bordering northern Vietnam. HIV-1 strains within each subtype were remarkably homogenous, with a mean intersubject DNA distance of 2.32% for subtype E and 1.13% for subtype C, respectively. Phylogenetic analysis of C2-V5 region of Guangxi subtype E env sequences revealed significant clustering with subtype E sequences from southern Vietnam and Cambodia. These results suggest that HIV-1 infection among heroin users in Guangxi represents two emerging epidemics initiated from distinct sources: one from Vietnam and another from Yunnan province. Factors associated with HIV-1 infection were not restricted to injection practices. Unprotected sexual behaviors are likely to increase the probability of HIV transmission beyond this high-risk population. Designing and implementing effective intervention strategies targeted toward both injection drug use and high risk sexual behavior are urgently needed to further reduce HIV-1 spread in China.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1525-4135
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pubmed:author |
pubmed-author:BeyrerCC,
pubmed-author:ChenJJ,
pubmed-author:Gurri-GlassGG,
pubmed-author:HUII,
pubmed-author:LalPP,
pubmed-author:LiangSS,
pubmed-author:LinKK,
pubmed-author:LiuWW,
pubmed-author:RAILG AGA,
pubmed-author:ViscidiR PRP,
pubmed-author:WangZZ,
pubmed-author:YangJJ,
pubmed-author:YuX FXF
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
180-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10843533-China,
pubmed-meshheading:10843533-DNA, Viral,
pubmed-meshheading:10843533-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10843533-Female,
pubmed-meshheading:10843533-Gene Products, env,
pubmed-meshheading:10843533-HIV Infections,
pubmed-meshheading:10843533-HIV-1,
pubmed-meshheading:10843533-Humans,
pubmed-meshheading:10843533-Male,
pubmed-meshheading:10843533-Molecular Sequence Data,
pubmed-meshheading:10843533-Phylogeny,
pubmed-meshheading:10843533-Polymerase Chain Reaction,
pubmed-meshheading:10843533-Prevalence,
pubmed-meshheading:10843533-Risk Factors,
pubmed-meshheading:10843533-Substance Abuse, Intravenous
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pubmed:year |
1999
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pubmed:articleTitle |
Emerging HIV infections with distinct subtypes of HIV-1 infection among injection drug users from geographically separate locations in Guangxi Province, China.
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pubmed:affiliation |
Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA. xfyu@jhsph.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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