Source:http://linkedlifedata.com/resource/pubmed/id/10841941
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|---|---|
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| lifeskim:mentions |
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umls-concept:C2003941,
umls-concept:C2349976,
umls-concept:C2911692
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| pubmed:issue |
2
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| pubmed:dateCreated |
2000-8-25
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| pubmed:abstractText |
Infection with atypical mycobacteria occurs mainly in patients with a compromised cellular immune system, in particular in those with a defective T cell or monocyte function. Here we analyzed the specific immune response of an adolescent HIV-negative patient with disseminated mycobacterium avium infection and fatal varizella zoster virus infection. The patient presented with dysplastic hematopoesis of all cell lineage's and a bicytopenia of erythrocytes and leukocytes, but a hematological malignancy could not be found. We found a peripheral lymphopenia and monocytopenia, as well as a lack of NK-cells and B-cells. Lymphocytes consisted of 95% T cells, which contained up to 40% of TCR gammadelta+CD4-CD8-T-cells (mainly TCR gamma9delta2), few monocytes and B-cells. Approximately 50% of CD3+ T-cells showed a CD57+ NK-like phenotype. Functional analysis of PBMC revealed a good antigen-specific T cell function if antigen-presenting cells were supplemented from a HLA-matched donor. Moreover, a strong M. avium specific cytotoxicity mediated by TCR alphabeta+T-cells could be found in vitro and even ex vivo. In contrast, NK-killing was absent. No evidence for a defect in IL-12 or IFN-gamma production and signaling were found. The data indicate that a strong alphabeta and gammadelta T cell immunity tries to compensate for a deficient monocyte and NK cell function in this patient.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0165-2478
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
72
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
75-82
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10841941-Adolescent,
pubmed-meshheading:10841941-Adult,
pubmed-meshheading:10841941-Chickenpox,
pubmed-meshheading:10841941-Cytotoxicity, Immunologic,
pubmed-meshheading:10841941-Fatal Outcome,
pubmed-meshheading:10841941-Female,
pubmed-meshheading:10841941-Humans,
pubmed-meshheading:10841941-Immunologic Deficiency Syndromes,
pubmed-meshheading:10841941-Killer Cells, Natural,
pubmed-meshheading:10841941-Leukopenia,
pubmed-meshheading:10841941-Lymphocyte Count,
pubmed-meshheading:10841941-Lymphopenia,
pubmed-meshheading:10841941-Male,
pubmed-meshheading:10841941-Monocytes,
pubmed-meshheading:10841941-Mycobacterium avium Complex,
pubmed-meshheading:10841941-Mycobacterium avium-intracellulare Infection,
pubmed-meshheading:10841941-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10841941-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:10841941-T-Lymphocytes, Cytotoxic
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| pubmed:year |
2000
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| pubmed:articleTitle |
Strong alpha beta and gamma delta TCR response in a patient with disseminated Mycobacterium avium infection and lack of NK cells and monocytopenia.
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| pubmed:affiliation |
Clinic for Rheumatology and Clinical Immunology/Allergology, University Hospital Bern, Freiburgstrasse, CH-3010, Bern, Switzerland.
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| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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