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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2000-7-13
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pubmed:abstractText |
A prospective study of high-risk commercial sex workers in Senegal has shown that HIV-2 infection may reduce the risk of subsequent HIV-1 infection; these findings have been confirmed and extended, now with 13 years of observation. While exploring the biological mechanisms behind this natural protection, we found that a significant proportion of peripheral blood mononuclear cells obtained from HIV-2-infected subjects resisted in vitro challenge with CCR5-dependent HIV-1 viruses but not CXCR4-dependent viruses. High levels of beta-chemokines, the natural ligands of the CCR5 coreceptor, were correlated with low levels of viral replication, and resistance was abrogated by antibodies to beta-chemokines. Our results suggest that beta-chemokine-mediated resistance may be an important correlate of HIV protection against HIV-1 infection and relevant to HIV vaccine design.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-10195268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-10233987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-10627569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-10720510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-2431484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-3132953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-7539936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-7909009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-7915856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8356453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8497055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8525373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8570619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8597950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8629022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8633095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8649511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8658171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8658172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8673922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8674119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8674120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8756719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8811338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8811351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8825754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8896248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-8986813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9060675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9108095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9120386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9188536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9223745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9230441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9236198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9287217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9343259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9367954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9371556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9468361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9468377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9495345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9499105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9520457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9557695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9621102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10841574-9649576
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6797-802
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10841574-AIDS Vaccines,
pubmed-meshheading:10841574-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10841574-Chemokines, CC,
pubmed-meshheading:10841574-Female,
pubmed-meshheading:10841574-HIV-1,
pubmed-meshheading:10841574-HIV-2,
pubmed-meshheading:10841574-Humans,
pubmed-meshheading:10841574-Prospective Studies,
pubmed-meshheading:10841574-Receptors, CCR5
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pubmed:year |
2000
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pubmed:articleTitle |
In vitro correlates of HIV-2-mediated HIV-1 protection.
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pubmed:affiliation |
Harvard AIDS Institute, Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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