|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2000-7-7
|
|
pubmed:abstractText |
[structure--see text] Bioassay-guided fractionation of extracts of the Palauan ascidian Didemnum guttatum led to the isolation of cyclodidemniserinol trisulfate (1) as an inhibitor of HIV-1 integrase, which is an attractive target for anti-retroviral chemotherapy. The structure of cyclodidemniserinol trisulfate (1), the stereochemistry of which was only partially determined, was elucidated by interpretation of NMR and mass spectral data.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Factors,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Topoisomerases, Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Integrase,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Integrase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Propylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfates,
http://linkedlifedata.com/resource/pubmed/chemical/Topoisomerase I Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/serinol
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1523-7060
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1605-7
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:10841490-Animals,
pubmed-meshheading:10841490-Anti-HIV Agents,
pubmed-meshheading:10841490-Biological Factors,
pubmed-meshheading:10841490-Cytomegalovirus,
pubmed-meshheading:10841490-DNA Topoisomerases, Type I,
pubmed-meshheading:10841490-Enzyme Inhibitors,
pubmed-meshheading:10841490-HIV Integrase,
pubmed-meshheading:10841490-HIV Integrase Inhibitors,
pubmed-meshheading:10841490-Lipid Metabolism,
pubmed-meshheading:10841490-Lipids,
pubmed-meshheading:10841490-Marine Biology,
pubmed-meshheading:10841490-Mass Spectrometry,
pubmed-meshheading:10841490-Molecular Structure,
pubmed-meshheading:10841490-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:10841490-Propylene Glycols,
pubmed-meshheading:10841490-Sulfates,
pubmed-meshheading:10841490-Topoisomerase I Inhibitors,
pubmed-meshheading:10841490-Urochordata
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Cyclodidemniserinol trisulfate, a sulfated serinolipid from the Palauan ascidian Didemnum guttatum that inhibits HIV-1 integrase.
|
|
pubmed:affiliation |
Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093-0212, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
