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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2000-8-15
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pubmed:abstractText |
Telomeres consist of repetitive (TTAGGG) DNA sequences that are maintained by the multisubunit telomerase ribonucleoprotein. Telomerase consists of an RNA, which serves as template for the sequence tracts, and a catalytic subunit that functions in reverse transcription of the RNA template. Cloning and characterization of the human catalytic subunit of telomerase (hTERT) has supported a role in cell transformation. How telomerase activity is regulated, however, is largely unknown.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-9822
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pubmed:author |
pubmed-author:ChenCC,
pubmed-author:DharSS,
pubmed-author:KharbandaSS,
pubmed-author:KufeDD,
pubmed-author:KumarVV,
pubmed-author:MajumderPP,
pubmed-author:PandevSS,
pubmed-author:PanditaT KTK,
pubmed-author:StraussWW,
pubmed-author:WeaverDD,
pubmed-author:WhangYY,
pubmed-author:YuanZ MZM
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
568-75
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10837221-Catalytic Domain,
pubmed-meshheading:10837221-Cells, Cultured,
pubmed-meshheading:10837221-DNA-Binding Proteins,
pubmed-meshheading:10837221-Fibroblasts,
pubmed-meshheading:10837221-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:10837221-Humans,
pubmed-meshheading:10837221-Immunoblotting,
pubmed-meshheading:10837221-Phosphorylation,
pubmed-meshheading:10837221-Precipitin Tests,
pubmed-meshheading:10837221-Proto-Oncogene Proteins c-abl,
pubmed-meshheading:10837221-RNA,
pubmed-meshheading:10837221-Telomerase,
pubmed-meshheading:10837221-Telomere,
pubmed-meshheading:10837221-Transfection
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pubmed:year |
2000
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pubmed:articleTitle |
Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase.
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pubmed:affiliation |
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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