Source:http://linkedlifedata.com/resource/pubmed/id/10837187
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2000-7-27
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| pubmed:abstractText |
In order to assess the relationship between human immunodeficiency virus (HIV) RNA, hepatitis C virus (HCV) RNA, CD4, CD8, and liver enzymes during combination antiretroviral therapy, these parameters were measured in 12 HIV-HCV-coinfected patients (who were naive for antiretrovirals) on the day before and 3, 7, 14, 28, 56, and 84 days after initiating the following treatments: stavudine and lamivudine in all patients, indinavir in 6 patients, and nevirapine in 6 patients. HIV RNA declined rapidly, CD4 cells increased slowly, and CD8 cells and liver enzymes were stable. HCV RNA showed a transient significant increase at days 14 and 21 (7.33+/-0.16 [mean +/- SE] and 7.29+/-0.2 log copies/mL vs. 7+/-0.2 log copies/mL at baseline; P<.05). These changes were similar in both treatment groups. A 2-fold alanine aminotransferase increase was observed in 4 of 12 patients; 4 of 4 patients showed increased HCV RNA. The relationship between HCV RNA increase and HIV RNA decrease indicates virus-virus interference. An HCV RNA increase may cause significant liver damage only in a minority of patients.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-1899
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| pubmed:author |
pubmed-author:CarosiGG,
pubmed-author:ChioderaAA,
pubmed-author:FavilliFF,
pubmed-author:GargiuloFF,
pubmed-author:PalvariniLL,
pubmed-author:PuotiMM,
pubmed-author:PutzoluVV,
pubmed-author:RoldanE QEQ,
pubmed-author:SpinettiAA,
pubmed-author:TuranoAA,
pubmed-author:ZaltronSS,
pubmed-author:ZaniniBB
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| pubmed:issnType |
Print
|
| pubmed:volume |
181
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2033-6
|
| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10837187-Adult,
pubmed-meshheading:10837187-Alanine Transaminase,
pubmed-meshheading:10837187-Anti-HIV Agents,
pubmed-meshheading:10837187-Drug Therapy, Combination,
pubmed-meshheading:10837187-HIV,
pubmed-meshheading:10837187-HIV Infections,
pubmed-meshheading:10837187-Hepacivirus,
pubmed-meshheading:10837187-Hepatitis C,
pubmed-meshheading:10837187-Humans,
pubmed-meshheading:10837187-Liver,
pubmed-meshheading:10837187-Male,
pubmed-meshheading:10837187-Pilot Projects,
pubmed-meshheading:10837187-RNA, Viral,
pubmed-meshheading:10837187-Virus Replication
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Liver damage and kinetics of hepatitis C virus and human immunodeficiency virus replication during the early phases of combination antiretroviral treatment.
|
| pubmed:affiliation |
Clinica di Malattie Infettive e Tropicali, Spedali Civili, P.le Ospedale Civili 1, I 25123 Brescia, Italy. puoti_brambilla@iol.it
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| pubmed:publicationType |
Journal Article
|