Linked Life Data

1083693

Source:http://linkedlifedata.com/resource/pubmed/id/1083693

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1976-7-6
pubmed:abstractText
Temporary electrophysiological damage to the rabbit eye proportional to dosis and application time was observed after application of Vincristin (Lilly). Cell destruction in all retinal layers was observed upon histological and electron microscopic examination of the animals. The outer segments of the receptor cells showed chiefly diffuse damage, and the pigment epithelial cells showed a high incidence of reorganization. Follow-up examination one year later showed this damage to be partially reparable, especially when very high doses had not been applied. Regeneration of the outer segments was observed. Destruction through pyknosis of the nucleus and cytoplasmal destruction was observed in a small number of receptor cells, bipolar ganglion cells, and ganglion cells. This also explained the absence of lasting functional abnormalities in the ERG and EVP.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0065-6100
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
199
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-56
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
[A histological and electron microscopic study of the rabbit retina after application of vincristin (author's transl)].
pubmed:publicationType
Journal Article, English Abstract