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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-7-31
pubmed:abstractText
Oligodendroglial tumors have been identified as a subgroup of glial neoplasms with a distinctly better response to chemotherapy and overall survival than purely astrocytic gliomas. Here we report our experience with adjuvant postirradiation and preirradiation chemotherapy using procarbazine, lomustine, and vincristine (PCV) in 27 patients with WHO grade II or III oligodendroglioma or oligoastrocytoma. The efficacy of chemotherapy was assessed according to the Macdonald response criteria (complete response, CR; partial response, PR; stable disease, SD; progressive disease, PD) and progression-free survival intervals by computed tomography or magnetic resonance imaging. First, we confirm that PCV salvage therapy for patients progressing after radiotherapy is highly effective (n = 11, 1 CR, 5 PR, 5 SD; median progression-free survival has not yet been reached, but is longer than 18 months). Second, 3 patients who received radiotherapy plus PCV as first-line therapy achieved CR and 2 achieved SD, and all 5 are progression-free with a median follow-up of 12 months. Third, given these encouraging results, 11 patients received postoperative preirradiation PCV chemotherapy and were given radiotherapy only upon progression. Preirradiation PCV chemotherapy was also effective (2 CR, 3 PR, 6 SD; median progression-free survival has not been yet reached, but is longer than 14 months). Patients with anaplastic oligoastrocytomas were as likely to respond to PCV chemotherapy, as were patients with anaplastic oligodendroglioma. Three patients who had previously responded to PCV were successfully treated with a second course of PCV upon recurrence. PCV chemotherapy was also effective in patients with leptomeningeal spread of oligodendrogliomas. A randomized prospective trial is required to compare the effectiveness and neurotoxicity of first-line PCV chemotherapy followed by radiotherapy to the traditional reverse sequence.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0340-5354
pubmed:author
pubmed:issnType
Print
pubmed:volume
247
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
297-302
pubmed:dateRevised
2006-4-24
pubmed:meshHeading
pubmed-meshheading:10836623-Adolescent, pubmed-meshheading:10836623-Adult, pubmed-meshheading:10836623-Aged, pubmed-meshheading:10836623-Antineoplastic Agents, Alkylating, pubmed-meshheading:10836623-Antineoplastic Agents, Phytogenic, pubmed-meshheading:10836623-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:10836623-Brain Neoplasms, pubmed-meshheading:10836623-Disease-Free Survival, pubmed-meshheading:10836623-Female, pubmed-meshheading:10836623-Humans, pubmed-meshheading:10836623-Lomustine, pubmed-meshheading:10836623-Male, pubmed-meshheading:10836623-Middle Aged, pubmed-meshheading:10836623-Oligodendroglioma, pubmed-meshheading:10836623-Procarbazine, pubmed-meshheading:10836623-Prospective Studies, pubmed-meshheading:10836623-Retrospective Studies, pubmed-meshheading:10836623-Time Factors, pubmed-meshheading:10836623-Vincristine
pubmed:year
2000
pubmed:articleTitle
A role for preirradiation PCV chemotherapy for oligodendroglial brain tumors.
pubmed:affiliation
Department of Neurology, Medical School, University of Tübingen, Germany.
pubmed:publicationType
Journal Article, Clinical Trial