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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1976-7-6
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pubmed:abstractText |
The effect of urethan on various spleen-lymphocyte functions was studied in the rat for 45 days after administration of the carcinogen. For 3 days following the last injection of urethan, the total cell number and LPS reactivity were greatly reduced. Certain reactivities, probably T-cell dependent functions, such as responsiveness to the in vitro mitogenic effect of PHA, Con A, and primary stimulation by histocompatibility alloantigens in the one-way reaction, were selectively enriched during the first 2 days. Thereafter several dissociations of these lymphocyte functions can be observed: i.e., various intervals succeed during which one function may be enriched and other(s) diminished. It seems that the kinetics of enrichment, decay and recovery of the T-cell subsets involved in the reactions investigated follow a distinctive profile for each one of them. It is suggested, as a working hypothesis, that the unbalanced situations derived from the time-course discordance of the quantitative changes in the various lymphocyte functions may allow, or even enhance, tumor development.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0300-8916
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
319-26
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pubmed:dateRevised |
2008-12-12
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pubmed:meshHeading |
pubmed-meshheading:1083573-Animals,
pubmed-meshheading:1083573-Antibody Formation,
pubmed-meshheading:1083573-Female,
pubmed-meshheading:1083573-HLA Antigens,
pubmed-meshheading:1083573-Immunity, Cellular,
pubmed-meshheading:1083573-Lymphocyte Activation,
pubmed-meshheading:1083573-Rats,
pubmed-meshheading:1083573-Spleen,
pubmed-meshheading:1083573-T-Lymphocytes,
pubmed-meshheading:1083573-Urethane
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pubmed:articleTitle |
Lymphocyte functions in the rat spleen at various times after urethan administration.
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pubmed:publicationType |
Journal Article
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