| pubmed-article:10835599 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10835599 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10835599 | lifeskim:mentions | umls-concept:C0037993 | lld:lifeskim |
| pubmed-article:10835599 | lifeskim:mentions | umls-concept:C0027540 | lld:lifeskim |
| pubmed-article:10835599 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:10835599 | lifeskim:mentions | umls-concept:C1514926 | lld:lifeskim |
| pubmed-article:10835599 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10835599 | pubmed:dateCreated | 2000-9-25 | lld:pubmed |
| pubmed-article:10835599 | pubmed:abstractText | Gene therapy applications of retroviral vectors derived from C-type retroviruses have been limited to introducing genes into dividing target cells. Here, we report genetically engineered C-type retroviral vectors derived from spleen necrosis virus (SNV), which are capable of infecting nondividing cells. This has been achieved by introducing a nuclear localization signal (NLS) sequence into the matrix protein (MA) of SNV by site-directed mutagenesis. This increased the efficiency of infecting nondividing cells and was sufficient to endow the virus with the capability to efficiently infect growth-arrested human T lymphocytes and quiescent primary monocyte-derived macrophages. We demonstrate that this vector actively penetrates the nucleus of a target cell, and has potential use as a gene therapy vector to transfer genes into nondividing cells. | lld:pubmed |
| pubmed-article:10835599 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10835599 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10835599 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10835599 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10835599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10835599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10835599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10835599 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10835599 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10835599 | pubmed:issn | 1087-0156 | lld:pubmed |
| pubmed-article:10835599 | pubmed:author | pubmed-author:PomerantzR... | lld:pubmed |
| pubmed-article:10835599 | pubmed:author | pubmed-author:DornburgRR | lld:pubmed |
| pubmed-article:10835599 | pubmed:author | pubmed-author:CichutekKK | lld:pubmed |
| pubmed-article:10835599 | pubmed:author | pubmed-author:ParveenZZ | lld:pubmed |
| pubmed-article:10835599 | pubmed:author | pubmed-author:EngelstädterM... | lld:pubmed |
| pubmed-article:10835599 | pubmed:author | pubmed-author:KrupetskyAA | lld:pubmed |
| pubmed-article:10835599 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10835599 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:10835599 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10835599 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10835599 | pubmed:pagination | 623-9 | lld:pubmed |
| pubmed-article:10835599 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10835599 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10835599 | pubmed:articleTitle | Spleen necrosis virus-derived C-type retroviral vectors for gene transfer to quiescent cells. | lld:pubmed |
| pubmed-article:10835599 | pubmed:affiliation | The Dorrance H. Hamilton Laboratories, Thomas Jefferson University, Division of Infectious Diseases, Center for Human Virology, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA. | lld:pubmed |
| pubmed-article:10835599 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10835599 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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