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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2000-6-27
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pubmed:abstractText |
Platelets become activated and accumulate in brain microvessels of the ischemic microvascular bed after experimental focal cerebral ischemia. The binding of glycoprotein IIb/IIIa (integrin alpha(IIb)beta(3)) on platelets to fibrinogen is the terminal step in platelet adhesion and aggregation. This study tests the hypothesis that inhibition of platelet-fibrin(ogen) interactions may prevent microvascular occlusion after experimental middle cerebral artery occlusion (MCA:O).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0039-2499
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1402-09; discussion 1409-10
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10835463-Animals,
pubmed-meshheading:10835463-Basal Ganglia,
pubmed-meshheading:10835463-Brain Ischemia,
pubmed-meshheading:10835463-Cerebral Hemorrhage,
pubmed-meshheading:10835463-Dose-Response Relationship, Drug,
pubmed-meshheading:10835463-Drug Evaluation, Preclinical,
pubmed-meshheading:10835463-Fibrinogen,
pubmed-meshheading:10835463-Infarction, Middle Cerebral Artery,
pubmed-meshheading:10835463-Male,
pubmed-meshheading:10835463-Microcirculation,
pubmed-meshheading:10835463-Oligopeptides,
pubmed-meshheading:10835463-Papio,
pubmed-meshheading:10835463-Peptides, Cyclic,
pubmed-meshheading:10835463-Platelet Activation,
pubmed-meshheading:10835463-Platelet Aggregation Inhibitors,
pubmed-meshheading:10835463-Platelet Glycoprotein GPIIb-IIIa Complex,
pubmed-meshheading:10835463-Reperfusion,
pubmed-meshheading:10835463-Vascular Patency
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pubmed:year |
2000
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pubmed:articleTitle |
Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia.
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pubmed:affiliation |
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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