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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-9-15
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pubmed:abstractText |
Voltage-sensitive calcium channel conductance is essential for the nervous system to signal a painful event. However, intrathecal administration of L-type calcium channel blockers does not provide analgesia. The present investigation was designed to assess the safety and analgesic efficacy of ziconotide, a new N-type calcium channel blocker, when administered intrathecally to patients with acute postoperative pain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1098-7339
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
274-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10834782-Acute Disease,
pubmed-meshheading:10834782-Adult,
pubmed-meshheading:10834782-Aged,
pubmed-meshheading:10834782-Aged, 80 and over,
pubmed-meshheading:10834782-Analgesia, Patient-Controlled,
pubmed-meshheading:10834782-Analgesics, Opioid,
pubmed-meshheading:10834782-Arthroplasty, Replacement, Hip,
pubmed-meshheading:10834782-Calcium Channel Blockers,
pubmed-meshheading:10834782-Calcium Channels, N-Type,
pubmed-meshheading:10834782-Double-Blind Method,
pubmed-meshheading:10834782-Female,
pubmed-meshheading:10834782-Humans,
pubmed-meshheading:10834782-Injections, Spinal,
pubmed-meshheading:10834782-Male,
pubmed-meshheading:10834782-Middle Aged,
pubmed-meshheading:10834782-Morphine,
pubmed-meshheading:10834782-Pain, Postoperative,
pubmed-meshheading:10834782-Pain Measurement,
pubmed-meshheading:10834782-Pilot Projects,
pubmed-meshheading:10834782-omega-Conotoxins
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pubmed:articleTitle |
Ziconotide, a new N-type calcium channel blocker, administered intrathecally for acute postoperative pain.
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pubmed:affiliation |
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06520-8051, USA. peter.atanassoff@yale.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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