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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2000-6-15
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pubmed:abstractText |
The effect of selective histamine H3-receptor antagonist thioperamide was studied on PTZ-induced seizures in mice. Thioperamide significantly protected clonic seizures induced by PTZ in a dose-dependent manner. The effect of thioperamide was completely countered by pretreatment with R (alpha)-methylhistamine (RAMH), a selective H3-receptor agonist suggesting that the observed effect of thioperamide was elicited by histamine H3-receptors. RAMH alone did not significantly modify PTZ seizures. The findings are consistent with a role for the histaminergic neuronal system in seizures and suggest that H3-receptors may play an important role in modulating clonic seizures induced by PTZ in mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
PL297-301
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10834305-Animals,
pubmed-meshheading:10834305-Dose-Response Relationship, Drug,
pubmed-meshheading:10834305-Histamine Antagonists,
pubmed-meshheading:10834305-Male,
pubmed-meshheading:10834305-Methylhistamines,
pubmed-meshheading:10834305-Mice,
pubmed-meshheading:10834305-Pentylenetetrazole,
pubmed-meshheading:10834305-Piperidines,
pubmed-meshheading:10834305-Protective Agents,
pubmed-meshheading:10834305-Receptors, Histamine H3,
pubmed-meshheading:10834305-Seizures
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pubmed:year |
2000
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pubmed:articleTitle |
Thioperamide, a selective histamine H3 receptor antagonist, protects against PTZ-induced seizures in mice.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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