| pubmed-article:1083376 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1083376 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:1083376 | lifeskim:mentions | umls-concept:C0036945 | lld:lifeskim |
| pubmed-article:1083376 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1083376 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
| pubmed-article:1083376 | lifeskim:mentions | umls-concept:C0040106 | lld:lifeskim |
| pubmed-article:1083376 | lifeskim:mentions | umls-concept:C0020522 | lld:lifeskim |
| pubmed-article:1083376 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1083376 | pubmed:dateCreated | 1976-7-6 | lld:pubmed |
| pubmed-article:1083376 | pubmed:abstractText | Calf thymosin was injected subcutaneously in daily doses of 0.1 to 3 mg for 12 to 15 days into adult thymectomized, irradiated, bone marrow-reconstituted (THXB) mice. Thymosin partially restored the ability of the T-cell-depleted host to develop delayed-type hypersensitivity to sheep erythrocytes. The degree of restoration varied from 50 to 75% of control values. Thymosin treatment of normal mice potentiated the footpad responsiveness to sheep erythrocytes by as much as 50% over that of untreated controls. The optimum dosage of thymosin seemed to be in the 200- to 500-mug range, and multiple injections were essential for a significant response. Tweleve daily injections of 100 to 500 mug of thymosin restored T-cell reactivity to the THXB mouse, but the responsiveness decayed relatively rapidly once the treatment was stopped. The restoration of immune responsiveness to sheep erythrocytes in T-cell-depleted mice provides a convenient means of demonstrating activity in thymosin preparations in vivo. | lld:pubmed |
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| pubmed-article:1083376 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1083376 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1083376 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1083376 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1083376 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1083376 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:1083376 | pubmed:author | pubmed-author:CollinsF MFM | lld:pubmed |
| pubmed-article:1083376 | pubmed:author | pubmed-author:MorrisonN ENE | lld:pubmed |
| pubmed-article:1083376 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1083376 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:1083376 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1083376 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1083376 | pubmed:pagination | 564-8 | lld:pubmed |
| pubmed-article:1083376 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1083376 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:1083376 | pubmed:articleTitle | Restoration of delayed hypersensitivity to sheep erythrocytes by thymosin treatment of T-cell-depleted mice. | lld:pubmed |
| pubmed-article:1083376 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1083376 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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