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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1976-7-6
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pubmed:abstractText |
Calf thymosin was injected subcutaneously in daily doses of 0.1 to 3 mg for 12 to 15 days into adult thymectomized, irradiated, bone marrow-reconstituted (THXB) mice. Thymosin partially restored the ability of the T-cell-depleted host to develop delayed-type hypersensitivity to sheep erythrocytes. The degree of restoration varied from 50 to 75% of control values. Thymosin treatment of normal mice potentiated the footpad responsiveness to sheep erythrocytes by as much as 50% over that of untreated controls. The optimum dosage of thymosin seemed to be in the 200- to 500-mug range, and multiple injections were essential for a significant response. Tweleve daily injections of 100 to 500 mug of thymosin restored T-cell reactivity to the THXB mouse, but the responsiveness decayed relatively rapidly once the treatment was stopped. The restoration of immune responsiveness to sheep erythrocytes in T-cell-depleted mice provides a convenient means of demonstrating activity in thymosin preparations in vivo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-1078552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-1079427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-1079428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-1079429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-1079437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-1090526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-236717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-4152201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-4540430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-4567643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-4587141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-4591170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-4598017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-48353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-4904881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-4938948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-4945476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-5230175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1083376-770334
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
564-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1083376-Animals,
pubmed-meshheading:1083376-Erythrocytes,
pubmed-meshheading:1083376-Foot,
pubmed-meshheading:1083376-Hindlimb,
pubmed-meshheading:1083376-Hypersensitivity, Delayed,
pubmed-meshheading:1083376-Mice,
pubmed-meshheading:1083376-Mice, Inbred C3H,
pubmed-meshheading:1083376-Mice, Inbred C57BL,
pubmed-meshheading:1083376-Radiation Chimera,
pubmed-meshheading:1083376-Sheep,
pubmed-meshheading:1083376-T-Lymphocytes,
pubmed-meshheading:1083376-Thymectomy,
pubmed-meshheading:1083376-Thymosin,
pubmed-meshheading:1083376-Thymus Extracts,
pubmed-meshheading:1083376-Time Factors
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pubmed:year |
1976
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pubmed:articleTitle |
Restoration of delayed hypersensitivity to sheep erythrocytes by thymosin treatment of T-cell-depleted mice.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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