Linked Life Data

10831121

Source:http://linkedlifedata.com/resource/pubmed/id/10831121

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-8-28
pubmed:abstractText
Cytotrophoblast cells, specialized placental cells, proliferate early in pregnancy and then differentiate into tumour-like cells that invade the uterus and its vasculature. We have established in vitro models of three-dimensional cultures for anchoring villi and cell islands on extracellular matrix in order to study regulation of cytotrophoblast cell differentiation and proliferation. It has been demonstrated that cytotrophoblast cells from cell islands and cell columns share the same characteristics and that their differentiation is triggered by interaction with the extracellular matrix. The fact that during much of the first trimester maternal blood flow to the placenta is at a minimum, suggests that oxygen tension might regulate cytotrophoblast proliferation and differentiation. Hypoxia, comparable to that encountered by early gestation cytotrophoblast cells in the intervillous space, stimulated the cells to enter the cell cycle and inhibited their differentiation along the invasive pathway. Thus, oxygen gradient and cell-matrix interactions at the maternal-fetal interface play an important role in the regulation of cytotrophoblast proliferation and differentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0143-4004
pubmed:author
pubmed:issnType
Print
pubmed:volume
21 Suppl A
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S45-9
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:articleTitle
Post-implantation differentiation and proliferation of cytotrophoblast cells: in vitro models--a review.
pubmed:affiliation
Department of Stomatology, University of California at San Francisco, 94143-0512, USA. krtolica@pacbell.net
pubmed:publicationType
Journal Article, Review