Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10830275rdf:typepubmed:Citationlld:pubmed
pubmed-article:10830275lifeskim:mentionsumls-concept:C0040300lld:lifeskim
pubmed-article:10830275lifeskim:mentionsumls-concept:C0229671lld:lifeskim
pubmed-article:10830275lifeskim:mentionsumls-concept:C0020663lld:lifeskim
pubmed-article:10830275lifeskim:mentionsumls-concept:C0597879lld:lifeskim
pubmed-article:10830275lifeskim:mentionsumls-concept:C0030685lld:lifeskim
pubmed-article:10830275lifeskim:mentionsumls-concept:C0680255lld:lifeskim
pubmed-article:10830275lifeskim:mentionsumls-concept:C0391871lld:lifeskim
pubmed-article:10830275lifeskim:mentionsumls-concept:C1283071lld:lifeskim
pubmed-article:10830275lifeskim:mentionsumls-concept:C1963578lld:lifeskim
pubmed-article:10830275lifeskim:mentionsumls-concept:C1880022lld:lifeskim
pubmed-article:10830275pubmed:issue6lld:pubmed
pubmed-article:10830275pubmed:dateCreated2000-6-15lld:pubmed
pubmed-article:10830275pubmed:abstractTextA novel RIA was used to examine the release of agouti-related protein-like immunoreactivity (AGRP-LI) from perfused rat hypothalamic tissue slices and to characterize AGRP-LI in rat serum. A continuous low level basal AGRP-LI release was observed from hypothalami of rats fed ad libitum before the rats were killed. Basal AGRP-LI release was 3-fold greater in rats fasted 48 h. In fasted animals leptin dose-dependently suppressed basal AGRP-LI release. In fed animals no change in basal AGRP-LI release was detected in response to 10(-6) M alpha-MSH, orexin B, melanin-concentrating hormone, or serotonin. HPLC analysis of AGRP-LI in rat serum identified a single peak that eluted in close proximity to synthetic AGRP (87-132) and mouse [Leu127Pro]AGRP and that was identical to the peak seen in hypothalamic and adrenal tissue extracts. The serum concentration of AGRP-LI in rats fed ad libitum was 0.865+/-0.323 nmol/liter (mean +/- SE). Food deprivation resulted in a slow, but statistically significant rise in serum immunoreactivity at 48 h [1.174+/-0.118 nmol/liter (mean +/- SE)]. Bilateral adrenalectomy did not change serum levels of AGRP-LI. These studies demonstrate that in the rat there are different levels of basal hypothalamic AGRP-LI release in fed and fasted states and that in the fasted rat this release can be profoundly suppressed by leptin. These studies also suggest that AGRP is present in the systemic circulation of rats.lld:pubmed
pubmed-article:10830275pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:languageenglld:pubmed
pubmed-article:10830275pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:citationSubsetAIMlld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10830275pubmed:statusMEDLINElld:pubmed
pubmed-article:10830275pubmed:monthJunlld:pubmed
pubmed-article:10830275pubmed:issn0013-7227lld:pubmed
pubmed-article:10830275pubmed:authorpubmed-author:LiJ YJYlld:pubmed
pubmed-article:10830275pubmed:authorpubmed-author:DickinsonCClld:pubmed
pubmed-article:10830275pubmed:authorpubmed-author:ZeniSSlld:pubmed
pubmed-article:10830275pubmed:authorpubmed-author:GanttGGlld:pubmed
pubmed-article:10830275pubmed:authorpubmed-author:BarshGGlld:pubmed
pubmed-article:10830275pubmed:authorpubmed-author:YangY KYKlld:pubmed
pubmed-article:10830275pubmed:authorpubmed-author:QuS YSYlld:pubmed
pubmed-article:10830275pubmed:authorpubmed-author:FinnissSSlld:pubmed
pubmed-article:10830275pubmed:issnTypePrintlld:pubmed
pubmed-article:10830275pubmed:volume141lld:pubmed
pubmed-article:10830275pubmed:ownerNLMlld:pubmed
pubmed-article:10830275pubmed:authorsCompleteYlld:pubmed
pubmed-article:10830275pubmed:pagination1942-50lld:pubmed
pubmed-article:10830275pubmed:dateRevised2011-8-3lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:meshHeadingpubmed-meshheading:10830275...lld:pubmed
pubmed-article:10830275pubmed:year2000lld:pubmed
pubmed-article:10830275pubmed:articleTitleAgouti-related protein-like immunoreactivity: characterization of release from hypothalamic tissue and presence in serum.lld:pubmed
pubmed-article:10830275pubmed:affiliationDepartment of Surgery, University of Michigan, Ann Arbor 48109-0682, USA.lld:pubmed
pubmed-article:10830275pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10830275pubmed:publicationTypeIn Vitrolld:pubmed
pubmed-article:10830275pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:10830275pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10830275lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:10830275lld:pubmed