Linked Life Data

10828865

Source:http://linkedlifedata.com/resource/pubmed/id/10828865

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2000-8-11
pubmed:abstractText
All patients receiving autografts for acute leukaemia in remission between 1 January 1981 and 31 December 1996 and reported to the European Group for Blood and Marrow Transplantation and had a relapse, were included. The patients underwent an allograft (n = 90, group A), were treated with chemotherapy (n = 2584, group B) or received a second autograft (n = 74, group C). The 2-year survival after relapse was 32 +/- 5%, 11 +/- 1% and 42 +/- 6% in groups A, B and C, respectively. In group A, those with an HLA-A, -B and -DR compatible related or unrelated donor had a 2-year survival of 37 +/- 7% compared to 13 +/- 8% for those receiving a graft from an HLA mismatched donor (n = 20). The following factors were associated with better survival in multivariate analyses: an interval from first autograft to relapse >5 months (P < 0.00001), a first autograft performed later than 1991 (P < 0.00001), patient age below 26 years (median, P < 0.002), group B vs HLA mismatches from group A (P = 0.002), group C vs group B (P < 0.005), patients who were not treated with total body irradiation at first autograft (P < 0.02) and patients in first remission at first autograft (P = 0.02). To conclude, the poor outcome in these patients was improved if a second autograft was feasible (P < 0.005), or if an HLA-matched allograft was performed (NS). Bone Marrow Transplantation (2000).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0268-3369
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1053-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10828865-Acute Disease, pubmed-meshheading:10828865-Adolescent, pubmed-meshheading:10828865-Adult, pubmed-meshheading:10828865-Aged, pubmed-meshheading:10828865-Bone Marrow Transplantation, pubmed-meshheading:10828865-Child, pubmed-meshheading:10828865-Child, Preschool, pubmed-meshheading:10828865-Female, pubmed-meshheading:10828865-Histocompatibility, pubmed-meshheading:10828865-Humans, pubmed-meshheading:10828865-Infant, pubmed-meshheading:10828865-Leukemia, pubmed-meshheading:10828865-Life Tables, pubmed-meshheading:10828865-Male, pubmed-meshheading:10828865-Middle Aged, pubmed-meshheading:10828865-Proportional Hazards Models, pubmed-meshheading:10828865-Recurrence, pubmed-meshheading:10828865-Remission Induction, pubmed-meshheading:10828865-Retrospective Studies, pubmed-meshheading:10828865-Salvage Therapy, pubmed-meshheading:10828865-Survival Analysis, pubmed-meshheading:10828865-Survival Rate, pubmed-meshheading:10828865-Sweden, pubmed-meshheading:10828865-Transplantation, Autologous, pubmed-meshheading:10828865-Transplantation, Homologous, pubmed-meshheading:10828865-Transplantation Conditioning, pubmed-meshheading:10828865-Treatment Outcome, pubmed-meshheading:10828865-Whole-Body Irradiation
pubmed:year
2000
pubmed:articleTitle
The dismal outcome in patients with acute leukaemia who relapse after an autograft is improved if a second autograft or a matched allograft is performed. Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT).
pubmed:affiliation
Centre for Allogeneic Stem Cell Transplantation, Huddinge Hospital, Sweden.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Multicenter Study