Linked Life Data

10828141

Source:http://linkedlifedata.com/resource/pubmed/id/10828141

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-7-24
pubmed:abstractText
Skin is one of several exposure routes whereby benzene, a widely distributed environmental contaminant that causes leukemia, enters the body, so accurate predictions of its percutaneous absorption are important for risk assessment. Determining benzene's skin-exposure dose and subsequent absorption is difficult because it has a low boiling point and exists as both liquid and vapor. Industrial and environmental benzene is present as a contaminant in other vehicles/solvents, and its percutaneous absorption is in part dependent upon co-solvent volatility. Co-solvents such as benzene in toluene rapidly evaporate from skin, whereas benzene contaminant in water is retained on skin longer due to water's lower volatility. Co-solvents can also affect benzene-skin partition coefficients; thus, permeability coefficients and percentage doses absorbed can vary many-fold. The exposure situation will determine percutaneous absorption, which, if low, can be overwhelmed by benzene intake from the food we eat and the air we breathe.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1077-3525
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
122-6
pubmed:dateRevised
2007-11-6
pubmed:meshHeading
pubmed:articleTitle
Benzene percutaneous absorption: dermal exposure relative to other benzene sources.
pubmed:affiliation
Department of Dermatology, School of Medicine, University of California, San Francisco, California 94143, USA.
pubmed:publicationType
Journal Article, Review