Linked Life Data

10828017

Source:http://linkedlifedata.com/resource/pubmed/id/10828017

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2000-6-29
pubmed:abstractText
Adult bone marrow is a major site for hematopoiesis, and reduction of the bone marrow cavity induces hematopoiesis in extramarrow tissues. To investigate the rudimentary intramarrow and the compensatory extramarrow hematopoiesis, particularly B lymphopoiesis, we used 3 osteopetrotic mouse strains [op/op, mi/mi, and Fos (-/-)], which are severely deficient in functional osteoclasts and therefore form inadequate bone marrow cavities. We found that bone marrow in these osteopetrotic mice supports myelopoiesis but not B lymphopoiesis, although cells that have the potential to differentiate into B lineage cells are present in the bone marrow. Although B lymphopoiesis normally occurs both in the spleen and liver of newborn mice, compensatory B lymphopoiesis in adult op/op and mi/mi mice is observed only in the liver, while myelopoiesis is enhanced in both organs. Interestingly, mice lacking the Fos proto-oncogene exhibit B lymphopoiesis in the spleen as well as liver. The amounts of expression of steel factor, Flt3/Flk-2 ligand, and interleukin-7 in the bone marrow, spleen, or liver were not significantly affected in these osteopetrotic mutants. These findings suggest that the volume of the bone marrow cavity regulates B lymphopoiesis without affecting the production of certain hematopoietic growth factors. The splenic microenvironments that support both myelopoiesis and B lymphopoiesis in the neonatal stage are lost in adults and are not reactivated even in the osteopetrotic adults unless the Fos gene is disrupted.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3363-70
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10828017-Aging, pubmed-meshheading:10828017-Animals, pubmed-meshheading:10828017-B-Lymphocytes, pubmed-meshheading:10828017-Bone Marrow Cells, pubmed-meshheading:10828017-Genes, fos, pubmed-meshheading:10828017-Hematopoiesis, pubmed-meshheading:10828017-Hematopoietic Stem Cells, pubmed-meshheading:10828017-Heterozygote, pubmed-meshheading:10828017-Homozygote, pubmed-meshheading:10828017-Interleukin-7, pubmed-meshheading:10828017-Liver, pubmed-meshheading:10828017-Mice, pubmed-meshheading:10828017-Mice, Inbred C57BL, pubmed-meshheading:10828017-Mice, Knockout, pubmed-meshheading:10828017-Osteopetrosis, pubmed-meshheading:10828017-Polymerase Chain Reaction, pubmed-meshheading:10828017-Proto-Oncogene Proteins, pubmed-meshheading:10828017-Proto-Oncogene Proteins c-fos, pubmed-meshheading:10828017-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:10828017-Spleen, pubmed-meshheading:10828017-Stem Cell Factor, pubmed-meshheading:10828017-fms-Like Tyrosine Kinase 3
pubmed:year
2000
pubmed:articleTitle
Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice.
pubmed:affiliation
Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't