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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2000-8-28
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pubmed:abstractText |
The physiological mechanism for producing antigen-specific antibodies is based on a two-phase neo-Darwinian process: the first phase consists of diversity generation (formation of the repertoire), and the second phase is antigen-mediated selection. In this article, we consider how the natural immunoglobulin gene-diversification processes can be exploited both in vivo and in vitro in order to allow the generation of novel antibody (and heterologous protein) repertoires.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0273-2289
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pubmed:author |
pubmed-author:BatistaF DFD,
pubmed-author:BemarkM PMP,
pubmed-author:BrüggemannMM,
pubmed-author:CumbersS JSJ,
pubmed-author:DaviesS LSL,
pubmed-author:EhrensteinM RMR,
pubmed-author:JollyC JCJ,
pubmed-author:LanoueAA,
pubmed-author:NeubergerM SMS,
pubmed-author:SHIHC YCY,
pubmed-author:WilliamsG TGT
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-60; discussion 60-2, 145-53
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10826948-Animals,
pubmed-meshheading:10826948-Antibodies, Monoclonal,
pubmed-meshheading:10826948-Antibody Affinity,
pubmed-meshheading:10826948-Antibody Diversity,
pubmed-meshheading:10826948-Antibody Specificity,
pubmed-meshheading:10826948-Cell Line,
pubmed-meshheading:10826948-Gene Rearrangement, B-Lymphocyte,
pubmed-meshheading:10826948-Genes, Immunoglobulin,
pubmed-meshheading:10826948-Humans,
pubmed-meshheading:10826948-Mice,
pubmed-meshheading:10826948-Mice, Transgenic,
pubmed-meshheading:10826948-Mutation,
pubmed-meshheading:10826948-Selection, Genetic
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pubmed:articleTitle |
Diversification and selection mechanisms for the production of protein repertoires: lessons from the immune system.
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pubmed:affiliation |
Medical Research Council Laboratory of Molecular Biology, Cambridge, NSW, Australia. msn@mrc-lmb.cam.ac.uk
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pubmed:publicationType |
Journal Article,
Review
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