Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:10826654rdf:typepubmed:Citationlld:pubmed
pubmed-article:10826654lifeskim:mentionsumls-concept:C0034721lld:lifeskim
pubmed-article:10826654lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:10826654lifeskim:mentionsumls-concept:C0014442lld:lifeskim
pubmed-article:10826654lifeskim:mentionsumls-concept:C0021852lld:lifeskim
pubmed-article:10826654lifeskim:mentionsumls-concept:C0023884lld:lifeskim
pubmed-article:10826654lifeskim:mentionsumls-concept:C0003174lld:lifeskim
pubmed-article:10826654lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:10826654lifeskim:mentionsumls-concept:C1512426lld:lifeskim
pubmed-article:10826654pubmed:issue1lld:pubmed
pubmed-article:10826654pubmed:dateCreated2000-6-13lld:pubmed
pubmed-article:10826654pubmed:abstractTextThe induction of a variety of drug-metabolizing enzymes by six anthraquinones (AQs) has been investigated in the liver and small intestine of rat. In the liver, the intragastric administration for 3 days of 100 mg/kg 9,10-anthraquinone (9,10-AQ). 1-hydroxy-AQ, 1,4-dihydroxy-AQ, but not 1,2-dihydroxy-AQ and 2-carboxy-AQ, resulted in a significant induction of the UDP-GT, DT-diaphorase, P450 1A-linked monooxygenase activities and in particular the methoxyresorufin-O-demethylase (MEROD), an activity dependent on P450 1A2. Immunoblot analysis indicated that 1-hydroxy-AQ and 1,4-dihydroxy-AQ induced P450 1A2 but not 1A1 and 9,10-AQ induced both P4501A2 and P4502B. Northern blotanalysis, using a cDNA probe for CYP 1A1 and CYP 1A2, confirmed that the AQs induce CYP 1A2 but not 1A1 mRNA. In the mucosa of small intestine, none of the above-mentioned enzymatic activities were enhanced following AQ administration. The induction mechanism of the hepatic enzymes by AQs is not known and it deserves a further study as it might be independent from the activation of the Ah-receptor as reported for other tricyclic compounds. The results from inhibition experiments showed that the hydroxylated AQs were strong inhibitors of P450 1A2-dependent monooxygenases. This suggests that long-term ingestion of certain AQs, may affect the toxicity of other components present in the diet through the hepatic induction or inhibition of P450 1A2.lld:pubmed
pubmed-article:10826654pubmed:languageenglld:pubmed
pubmed-article:10826654pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10826654pubmed:citationSubsetIMlld:pubmed
pubmed-article:10826654pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10826654pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10826654pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10826654pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10826654pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10826654pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10826654pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10826654pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:10826654pubmed:statusMEDLINElld:pubmed
pubmed-article:10826654pubmed:monthAprlld:pubmed
pubmed-article:10826654pubmed:issn0009-2797lld:pubmed
pubmed-article:10826654pubmed:authorpubmed-author:SalvettiAAlld:pubmed
pubmed-article:10826654pubmed:authorpubmed-author:AmatoGGlld:pubmed
pubmed-article:10826654pubmed:authorpubmed-author:GervasiP GPGlld:pubmed
pubmed-article:10826654pubmed:authorpubmed-author:LongoVVlld:pubmed
pubmed-article:10826654pubmed:issnTypePrintlld:pubmed
pubmed-article:10826654pubmed:day14lld:pubmed
pubmed-article:10826654pubmed:volume126lld:pubmed
pubmed-article:10826654pubmed:ownerNLMlld:pubmed
pubmed-article:10826654pubmed:authorsCompleteYlld:pubmed
pubmed-article:10826654pubmed:pagination63-77lld:pubmed
pubmed-article:10826654pubmed:dateRevised2007-11-15lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:meshHeadingpubmed-meshheading:10826654...lld:pubmed
pubmed-article:10826654pubmed:year2000lld:pubmed
pubmed-article:10826654pubmed:articleTitleHeterogenous effects of anthraquinones on drug-metabolizing enzymes in the liver and small intestine of rat.lld:pubmed
pubmed-article:10826654pubmed:affiliationLaboratory of Genetic and Biochemical Toxicology, Istituto di Mutagenesi e Differenziamento del CNR, Pisa, Italy.lld:pubmed
pubmed-article:10826654pubmed:publicationTypeJournal Articlelld:pubmed