Linked Life Data

1082631

Source:http://linkedlifedata.com/resource/pubmed/id/1082631

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1976-4-10
pubmed:abstractText
The thymocyte population of mice treated with cortisone was examined at various times with respect to its relative capacity to be triggered to DNA synthesis by soluble phytomitogens or mitogenic factors (MF) released by lymph node cells exposed to phytomitogens. The capacity of the thymocyte population to produce MF in response to phytomitogen exposure was also examined. We found that the relative blastogenic activity of both phytomitogens and MF on thymocytes increased as the cell number of the thymus was reduced by the cortisone treatment. However, the reactivity to phytomitogens increased to a higher extent. During the subsequent regeneration of the organ the stimulability of the cells by phytomitogen decreased far below that of MF. The relative capacity of thymocytes to produce MF seemed to parallel their phytomitogen reactivities. One possible explanation of the results is that there exists one subpopulation of cells in the thymus more responsive to phytomitogens than to MF and another more responsive to MF than to phytomitogen. It is possible that the cells that are phytomitogen-responsive are those that can produce MF.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
791-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Evidence of different cell populations in the mouse thymus releasing and responding to mitogenic factor.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.