| pubmed-article:10825133 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10825133 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10825133 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:10825133 | lifeskim:mentions | umls-concept:C0012568 | lld:lifeskim |
| pubmed-article:10825133 | lifeskim:mentions | umls-concept:C1749568 | lld:lifeskim |
| pubmed-article:10825133 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:10825133 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10825133 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:10825133 | pubmed:dateCreated | 2000-6-13 | lld:pubmed |
| pubmed-article:10825133 | pubmed:abstractText | The effects of exposure to high and very low fluence alpha-particles on the G1 checkpoint were investigated in human diploid fibroblasts irradiated and released from density-inhibited confluent cultures by the use of the cumulative labeling index method. Transient and permanent arrests in G1 occurred in fibroblast populations exposed to mean doses as low as 1 cGy, suggesting that nontraversed bystander cells may contribute to the low dose response. In cells exposed to high fluences, the G1 checkpoint is at least as extensive as in gamma-irradiated cells. In contrast to gamma-irradiated cells, neither repair of potentially lethal damage nor a reduction in the fraction of cells transiently or permanently arrested in G1 were observed in cells held in confluence for 6 h after alpha-particle irradiation. Studies with isogenic wild-type, p53-/-, and p21Waf1-/- mouse embryo fibroblasts exposed to either gamma or alpha-particle radiation revealed a total lack of G1 arrest in either p53-/- or p21waf1-/- cells, indicating that the G1 checkpoint in wild-type cells is p53-dependent and that p21Wf1 fully mediates the role of p53 in its induction. In contrast to human cells, mouse embryo fibroblasts do not undergo a permanent G1 arrest. Except under conditions favoring potentially lethal damage repair, a comparable expression pattern of p53, p21Waf1, and other cell cycle-regulated proteins (pRb, p34cdc2, and cyclin B1) was observed in alpha-particle or gamma-irradiated human fibroblasts. | lld:pubmed |
| pubmed-article:10825133 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825133 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10825133 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825133 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10825133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10825133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10825133 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825133 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10825133 | pubmed:month | May | lld:pubmed |
| pubmed-article:10825133 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:10825133 | pubmed:author | pubmed-author:LittleJ BJB | lld:pubmed |
| pubmed-article:10825133 | pubmed:author | pubmed-author:de ToledoS... | lld:pubmed |
| pubmed-article:10825133 | pubmed:author | pubmed-author:WakerA JAJ | lld:pubmed |
| pubmed-article:10825133 | pubmed:author | pubmed-author:AzzamE IEI | lld:pubmed |
| pubmed-article:10825133 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10825133 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10825133 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:10825133 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10825133 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10825133 | pubmed:pagination | 2623-31 | lld:pubmed |
| pubmed-article:10825133 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10825133 | pubmed:meshHeading | pubmed-meshheading:10825133... | lld:pubmed |
| pubmed-article:10825133 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10825133 | pubmed:articleTitle | High and low fluences of alpha-particles induce a G1 checkpoint in human diploid fibroblasts. | lld:pubmed |
| pubmed-article:10825133 | pubmed:affiliation | Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:10825133 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10825133 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10825133 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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