| pubmed-article:10825126 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10825126 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:10825126 | lifeskim:mentions | umls-concept:C1332002 | lld:lifeskim |
| pubmed-article:10825126 | lifeskim:mentions | umls-concept:C0007603 | lld:lifeskim |
| pubmed-article:10825126 | lifeskim:mentions | umls-concept:C0392752 | lld:lifeskim |
| pubmed-article:10825126 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:10825126 | pubmed:dateCreated | 2000-6-13 | lld:pubmed |
| pubmed-article:10825126 | pubmed:abstractText | Tumor cells may display a multidrug resistant phenotype by overexpression of ATP-binding cassette transporters such as multidrug resistance (MDRI) P-glycoprotein, multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP). The presence of BCRP has thus far been reported solely using mRNA data. In this study, we describe a BCRP-specific monoclonal antibody, BXP-34, obtained from mice, immunized with mitoxantrone-resistant, BCRP mRNA-positive MCF-7 MR human breast cancer cells. BCRP was detected in BCRP-transfected cells and in several mitoxantrone- and topotecan-selected tumor cell sublines. Pronounced staining of the cell membranes showed that the transporter is mainly present at the plasma membrane. In a panel of human tumors, including primary tumors as well as drug-treated breast cancer and acute myeloid leukemia samples, BCRP was low or undetectable. Extended studies will be required to analyze the possible contribution of BCRP to clinical multidrug resistance. | lld:pubmed |
| pubmed-article:10825126 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825126 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10825126 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825126 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10825126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10825126 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10825126 | pubmed:month | May | lld:pubmed |
| pubmed-article:10825126 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:ScheperR JRJ | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:AllenJ DJD | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:de JongM CMC | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:RossD DDD | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:DaltonW SWS | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:SchefferG LGL | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:MaliepaardMM | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:SchellensJ... | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:SchroeijersA... | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:10825126 | pubmed:author | pubmed-author:PijnenborgA... | lld:pubmed |
| pubmed-article:10825126 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10825126 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10825126 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:10825126 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10825126 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10825126 | pubmed:pagination | 2589-93 | lld:pubmed |
| pubmed-article:10825126 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10825126 | pubmed:meshHeading | pubmed-meshheading:10825126... | lld:pubmed |
| pubmed-article:10825126 | pubmed:meshHeading | pubmed-meshheading:10825126... | lld:pubmed |
| pubmed-article:10825126 | pubmed:meshHeading | pubmed-meshheading:10825126... | lld:pubmed |
| pubmed-article:10825126 | pubmed:meshHeading | pubmed-meshheading:10825126... | lld:pubmed |
| pubmed-article:10825126 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10825126 | pubmed:articleTitle | Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines. | lld:pubmed |
| pubmed-article:10825126 | pubmed:affiliation | Department of Pathology, Free University Hospital, Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:10825126 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10825126 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10825126 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10825126 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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