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rdf:type |
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lifeskim:mentions |
umls-concept:C0018134,
umls-concept:C0039194,
umls-concept:C0079189,
umls-concept:C0086972,
umls-concept:C0205054,
umls-concept:C0205225,
umls-concept:C0205263,
umls-concept:C0221198,
umls-concept:C0521378,
umls-concept:C0591833,
umls-concept:C1332714,
umls-concept:C1979963,
umls-concept:C2003903
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pubmed:issue |
4
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pubmed:dateCreated |
2000-7-27
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pubmed:abstractText |
We have previously reported that CD4+ T cells induced primary biliary cirrhosis (PBC)-like hepatic lesions in mice with graft-versus-host reaction due to major histocompatibility complex class II disparity. To clarify the relationship between the cytokine profile produced by CD4+ T cells and the formation of hepatic lesions, we sorted CD4+ T cells from the liver by using flow cytometry and examined their cytokine mRNA expression at various times after GVHR induction. We also examined the associated changes in the serum levels of antimitochondrial antibodies (AMA).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0815-9319
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
443-51
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10824891-Animals,
pubmed-meshheading:10824891-Autoantibodies,
pubmed-meshheading:10824891-Biological Markers,
pubmed-meshheading:10824891-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10824891-Cell Separation,
pubmed-meshheading:10824891-Cell Transplantation,
pubmed-meshheading:10824891-DNA Primers,
pubmed-meshheading:10824891-Female,
pubmed-meshheading:10824891-Flow Cytometry,
pubmed-meshheading:10824891-Gene Expression,
pubmed-meshheading:10824891-Genes, MHC Class II,
pubmed-meshheading:10824891-Graft vs Host Disease,
pubmed-meshheading:10824891-Interferon-gamma,
pubmed-meshheading:10824891-Interleukin-10,
pubmed-meshheading:10824891-Liver Cirrhosis, Biliary,
pubmed-meshheading:10824891-Liver Cirrhosis, Experimental,
pubmed-meshheading:10824891-Mice,
pubmed-meshheading:10824891-Mice, Inbred C57BL,
pubmed-meshheading:10824891-Mitochondria, Liver,
pubmed-meshheading:10824891-RNA, Messenger,
pubmed-meshheading:10824891-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10824891-Spleen
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pubmed:year |
2000
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pubmed:articleTitle |
Cytokine profile of liver-infiltrating CD4+ T cells separated from murine primary biliary cirrhosis-like hepatic lesions induced by graft-versus-host reaction.
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pubmed:affiliation |
Division of Gastroenterology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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