Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-9-20
pubmed:abstractText
Three new flavonoid glycosides, together with 15 known flavonoids, have been isolated from the leaves of Eriobotrya japonica, and characterized as (2S)- and (2R)-naringenin 8-C-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosides, and cinchonain Id 7-O-beta-D-glucopyranoside, respectively, based on spectral analyses including two dimensional (2D) NMR techniques. Higher proanthocyanidin fraction in the water-soluble portion of the extract was characterized as a procyanidin oligomer mixture mainly composed of undecameric procyanidin. These polyphenols have also been assessed for cytotoxic activity against two human oral tumor (human squamous cell carcinoma and human salivary gland tumor) cell lines. Selective cytotoxicity of the procyanidin oligomer between tumor and normal gingival fibroblast cells, and its possible mechanism, were also described.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0009-2363
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
687-93
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:10823708-Antibodies, Monoclonal, pubmed-meshheading:10823708-Antineoplastic Agents, Phytogenic, pubmed-meshheading:10823708-Apoptosis, pubmed-meshheading:10823708-Biflavonoids, pubmed-meshheading:10823708-Catechin, pubmed-meshheading:10823708-DNA Fragmentation, pubmed-meshheading:10823708-Drug Screening Assays, Antitumor, pubmed-meshheading:10823708-Electrophoresis, Agar Gel, pubmed-meshheading:10823708-Flavonoids, pubmed-meshheading:10823708-Glycosides, pubmed-meshheading:10823708-Humans, pubmed-meshheading:10823708-Immunohistochemistry, pubmed-meshheading:10823708-Molecular Weight, pubmed-meshheading:10823708-Mouth Neoplasms, pubmed-meshheading:10823708-Phenols, pubmed-meshheading:10823708-Plants, Medicinal, pubmed-meshheading:10823708-Proanthocyanidins, pubmed-meshheading:10823708-Tumor Cells, Cultured
pubmed:year
2000
pubmed:articleTitle
Polyphenols from Eriobotrya japonica and their cytotoxicity against human oral tumor cell lines.
pubmed:affiliation
Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Japan.
pubmed:publicationType
Journal Article