Linked Life Data

10823600

Source:http://linkedlifedata.com/resource/pubmed/id/10823600

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-8-15
pubmed:abstractText
This study describes the prevalence and demographics of avascular necrosis (AVN) in children with acute lymphoblastic leukemia (ALL). With improving survival of ALL patients on modern chemotherapy regimens, an increasing number of children with AVN will be presenting to orthopaedists. From 1991 to 1996, 202 patients were treated for ALL at a major tertiary pediatric cancer referral center. Eight patients (4.0%) subsequently developed AVN at an average of 30.0 months after beginning chemotherapy. A total of 27 documented joints were involved, with an average of 3.4 joints affected per patient diagnosed with AVN. The subset of patients with high-risk ALL who underwent an aggressive chemotherapy protocol was particularly susceptible to developing AVN. Six of 58 high-risk ALL patients (10.3%) developed AVN at an average of 18.5 months. As ALL patients now frequently survive into adulthood, orthopaedists will be increasingly called on to manage AVN affecting multiple joints in children and young adults.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0271-6798
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Avascular necrosis in children with acute lymphoblastic leukemia.
pubmed:affiliation
Division of Orthopaedic Surgery, Children's Hospital of Philadelphia, Pennsylvania, USA.
pubmed:publicationType
Journal Article