Source:http://linkedlifedata.com/resource/pubmed/id/10823583
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2000-7-18
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| pubmed:abstractText |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a drug that induces parkinsonism in humans and non-human primates. Free radicals are thought to be involved in its mechanism of action. Recently, metallothionein has been proposed to play a role as a scavenger of free radicals. In the present work, we studied the effect of MPTP neurotoxicity on brain metallothionein-I (MT-I) mRNA expression. Male C-57 black mice were treated with MPTP (30 mg/kg, i.p., daily) for 3 or 5 days. All animals were killed by cervical dislocation 7 days after the last MPTP dose. The brains were removed quickly and immediately frozen, and quantitative in situ hybridization was performed using MT-I cDNA probe. MT-I mRNA content in striatum, a region which is known to be highly predisposed and sensitive to MPTP-induced oxidative stress, decreased by 30% (3 days) and 39% (5 days) respectively, after the last MPTP administration. These results suggest that MT-I gene expression is decreased in MPTP neurotoxicity. It is suggested that the reduction of MT, an anti-oxidant and a free radical scavenger, in the striatum by MPTP enables the neurotoxin to exert maximal oxidative damage to the striatum.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-4-phenyl-1,2,3,6-tetrahydro...,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Metallothionein,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc Sulfate
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0364-3190
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
25
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
503-9
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10823583-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:10823583-Animals,
pubmed-meshheading:10823583-Autoradiography,
pubmed-meshheading:10823583-Brain,
pubmed-meshheading:10823583-Cerebral Cortex,
pubmed-meshheading:10823583-Corpus Striatum,
pubmed-meshheading:10823583-Free Radical Scavengers,
pubmed-meshheading:10823583-Gene Expression,
pubmed-meshheading:10823583-In Situ Hybridization,
pubmed-meshheading:10823583-Liver,
pubmed-meshheading:10823583-MPTP Poisoning,
pubmed-meshheading:10823583-Male,
pubmed-meshheading:10823583-Metallothionein,
pubmed-meshheading:10823583-Mice,
pubmed-meshheading:10823583-Mice, Inbred C57BL,
pubmed-meshheading:10823583-Neurons,
pubmed-meshheading:10823583-Organ Specificity,
pubmed-meshheading:10823583-Oxidative Stress,
pubmed-meshheading:10823583-RNA, Messenger,
pubmed-meshheading:10823583-Rats,
pubmed-meshheading:10823583-Zinc Sulfate
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| pubmed:year |
2000
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| pubmed:articleTitle |
MPTP decreases MT-I mRNA in mouse striatum.
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| pubmed:affiliation |
Laboratory of Neurotoxicology, Instituto Nacional de Neurología y Neurocirugía, México City, México.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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