| pubmed-article:10823461 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10823461 | lifeskim:mentions | umls-concept:C0003402 | lld:lifeskim |
| pubmed-article:10823461 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
| pubmed-article:10823461 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:10823461 | lifeskim:mentions | umls-concept:C0011175 | lld:lifeskim |
| pubmed-article:10823461 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:10823461 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:10823461 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10823461 | pubmed:dateCreated | 2000-8-9 | lld:pubmed |
| pubmed-article:10823461 | pubmed:abstractText | Liposomes composed of egg phosphatidylcholine (EPC) (13.4%, of the acyl chains being polyunsaturated fatty acids (PUFA)) and EPC/cholesterol (10:1 mol/mol) were studied for factors that affect liposomal lipid oxidative damage and hydrolysis upon long-term (16 months) storage. Factors studied include: (1) levels of lipid/water interface hydration, related to the presence of cholesterol in the lipid bilayer; (2) the membrane-associated antioxidant vitamin E; (3) the water-soluble antioxidant Tempol; and (4) exposure to light. Liposomal dispersions were stored at room temperature, either exposed to or protected from daylight, for a period of 16 months. Chemical and physical changes were monitored at several time points to assess oxidative and hydrolytic degradation of liposomal lipids. The conclusions of the study are: (1) PUFA are the most sensitive component of the liposome bilayer to oxidative degradation damage during long-term storage; (2) EPC liposomes are more sensitive to degradation during storage than EPC cholesterol liposomes, the presence of cholesterol in the lipid bilayer having a protective effect, probably due to its effect in decreasing the lipid-bilayer hydration; (3) oxidative degradation is the major process during long-term storage, having an earlier onset than the hydrolytic degradation: and (4) Tempol provided significantly better protection than vitamin E to EPC liposomal PUFA against oxidative damage during long-term storage. The relevance of cholesterol's presence, as a 'drying agent', in membranes containing PUFA to resistance of biological membranes to oxidative damage is discussed. | lld:pubmed |
| pubmed-article:10823461 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10823461 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10823461 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10823461 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10823461 | pubmed:issn | 0009-3084 | lld:pubmed |
| pubmed-article:10823461 | pubmed:author | pubmed-author:BarenholzYY | lld:pubmed |
| pubmed-article:10823461 | pubmed:author | pubmed-author:LipmanAA | lld:pubmed |
| pubmed-article:10823461 | pubmed:author | pubmed-author:SamuniA MAM | lld:pubmed |
| pubmed-article:10823461 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10823461 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:10823461 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10823461 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10823461 | pubmed:pagination | 121-34 | lld:pubmed |
| pubmed-article:10823461 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10823461 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10823461 | pubmed:articleTitle | Damage to liposomal lipids: protection by antioxidants and cholesterol-mediated dehydration. | lld:pubmed |
| pubmed-article:10823461 | pubmed:affiliation | Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel. samunia@cc.huji.ac.il | lld:pubmed |
| pubmed-article:10823461 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10823461 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10823461 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10823461 | lld:pubmed |
