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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0017337,
umls-concept:C0023745,
umls-concept:C0034987,
umls-concept:C0037047,
umls-concept:C0170657,
umls-concept:C0205245,
umls-concept:C0240069,
umls-concept:C0599883,
umls-concept:C1709450,
umls-concept:C1882417
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pubmed:issue |
2
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pubmed:dateCreated |
2000-8-3
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pubmed:abstractText |
A functional polymorphism in the regulatory region of the serotonin transporter gene (5-HTTLPR) has been reported to be both associated and linked to anxiety-related personality measures, although other studies have not replicated these findings. The current study examines both association and linkage of the gene to two major anxiety-related personality measures, the harm avoidance scale on the Tridimensional Personality Questionnaire and the neuroticism scale of the NEO-PI-R, in a sample of 148 Israeli subjects comprising 74 same-sex sibling pairs. We replicated the reported association between the short allele and higher scores on the TPQ harm avoidance scale (P = 0.03), including the subscale of shyness (P = 0.02), and also found association in the same direction between the short allele and the NEO-PI-R neuroticism subscales of anxiety (P = 0.03) and depression (P = 0.04). Sib-pair linkage analysis, using the regression method, further supported a role of the 5-HTTLPR in anxiety-related personality traits.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1359-4184
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
216-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10822353-Adolescent,
pubmed-meshheading:10822353-Adult,
pubmed-meshheading:10822353-Aged,
pubmed-meshheading:10822353-Anxiety,
pubmed-meshheading:10822353-Carrier Proteins,
pubmed-meshheading:10822353-Exploratory Behavior,
pubmed-meshheading:10822353-Female,
pubmed-meshheading:10822353-Genetic Linkage,
pubmed-meshheading:10822353-Humans,
pubmed-meshheading:10822353-Israel,
pubmed-meshheading:10822353-Jews,
pubmed-meshheading:10822353-Male,
pubmed-meshheading:10822353-Membrane Glycoproteins,
pubmed-meshheading:10822353-Membrane Transport Proteins,
pubmed-meshheading:10822353-Middle Aged,
pubmed-meshheading:10822353-Nerve Tissue Proteins,
pubmed-meshheading:10822353-Neurotic Disorders,
pubmed-meshheading:10822353-Nuclear Family,
pubmed-meshheading:10822353-Personality,
pubmed-meshheading:10822353-Polymorphism, Genetic,
pubmed-meshheading:10822353-Questionnaires,
pubmed-meshheading:10822353-Serotonin Plasma Membrane Transport Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs.
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pubmed:affiliation |
Beer Sheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, POB 4600, Beer Sheva, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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