Source:http://linkedlifedata.com/resource/pubmed/id/10821988
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2000-8-17
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pubmed:abstractText |
Clinical trials carried out to compare methadone and buprenorphine in the treatment of opioid dependence have generally employed an alcoholic solution of buprenorphine, which has a bioavailability superior to that of the tablets. Since the product available for large scale use is in tablet form, one intended to verify the efficacy of this formulation. In a multicentre randomised controlled double blind study, 72 opioid dependent patients were assigned to treatment with buprenorphine (8 mg/day) or methadone (60 mg/day) for a period of 6 months. The two compounds did not show any significant difference with regard to urinalyses: the average percentage of analyses proving negative was 60.4% for patients assigned to buprenorphine, and 65.5% for those assigned to methadone. With regard to retention, a non-significant trend in favour of methadone was observed. Patients completing the trial improved significantly in terms of psychosocial adjustment and global functioning, as ascertained by the DSM-IV-GAF and symptom checklist-90 (SCL-90) scales, and this was independent of the treatment group. Finally, in the case of buprenorphine, patients who dropped out differed significantly from those who stayed, in terms of a higher level of psychopathological symptoms, and a lower level of psychosocial functioning. The results of the study further support the utility of buprenorphine for the treatment of opioid dependence.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0376-8716
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10821988-Adolescent,
pubmed-meshheading:10821988-Adult,
pubmed-meshheading:10821988-Behavior, Addictive,
pubmed-meshheading:10821988-Buprenorphine,
pubmed-meshheading:10821988-Double-Blind Method,
pubmed-meshheading:10821988-Female,
pubmed-meshheading:10821988-Humans,
pubmed-meshheading:10821988-Male,
pubmed-meshheading:10821988-Methadone,
pubmed-meshheading:10821988-Multivariate Analysis,
pubmed-meshheading:10821988-Narcotics,
pubmed-meshheading:10821988-Opioid-Related Disorders,
pubmed-meshheading:10821988-Tablets
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pubmed:year |
2000
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pubmed:articleTitle |
Buprenorphine: a controlled clinical trial in the treatment of opioid dependence.
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pubmed:affiliation |
Servizio Tossicodipendenze Azienda USL 8, Cagliari, Italy. pallolo@tin.it
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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