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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-6-21
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pubmed:abstractText |
Motor neurons have been known to require a wide variety of neurotrophic factors for their survival. As one of the target-derived trophic factors, glial cell line-derived neurotrophic factor (GDNF) has been shown to exert its effects on motor neurons via a receptor complex including GDNF receptor alpha 1 (GFR alpha-1). Immunoreactivity of GFR alpha-1 was observed at myelinated peripheral nerves and neuromuscular junction (NMJ) of human skeletal muscles. Reverse transcriptase polymerase chain reaction (RT-PCR) analyses showed that mRNA of GFR alpha-1 existed in the ventral horn of human spinal cord, but not in the skeletal muscles. The results suggested that GFR alpha-1 might play a key role for uptake and internalization of GDNF at the human NMJ.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GDNF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GFRA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Cell Line-Derived...,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Cell Line-Derived...,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ret,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Ret oncogene protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
269
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10821644-Drosophila Proteins,
pubmed-meshheading:10821644-Glial Cell Line-Derived Neurotrophic Factor,
pubmed-meshheading:10821644-Glial Cell Line-Derived Neurotrophic Factor Receptors,
pubmed-meshheading:10821644-Humans,
pubmed-meshheading:10821644-Immunohistochemistry,
pubmed-meshheading:10821644-Motor Neurons,
pubmed-meshheading:10821644-Myelin Sheath,
pubmed-meshheading:10821644-Nerve Growth Factors,
pubmed-meshheading:10821644-Nerve Tissue Proteins,
pubmed-meshheading:10821644-Neuromuscular Junction,
pubmed-meshheading:10821644-Peripheral Nerves,
pubmed-meshheading:10821644-Proto-Oncogene Proteins,
pubmed-meshheading:10821644-Proto-Oncogene Proteins c-ret,
pubmed-meshheading:10821644-RNA, Messenger,
pubmed-meshheading:10821644-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:10821644-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10821644-Spinal Cord
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pubmed:year |
1999
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pubmed:articleTitle |
Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves.
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pubmed:affiliation |
Department of Neuromuscular Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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