Linked Life Data

10821467

Source:http://linkedlifedata.com/resource/pubmed/id/10821467

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Suppl
pubmed:dateCreated
2000-8-11
pubmed:abstractText
A variety of exciting and important new observations regarding the pathogenesis of nontypable H. influenzae infection have been made in the past decade. The interactions between mucin and OMPs show a high degree of specificity. Multiple adhesins have been identified on the bacterial surface. Colonization of the upper respiratory tract is a dynamic process. Immunodominant, antigenically heterogeneous OMPs are the targets of strain-specific immune responses, accounting in part for the recurrent nature of OM in otitis-prone children. The LOS of nontypable H. influenzae displays a remarkable degree of antigenic and phase variation and may be involved in molecular mimicry of host antigens. Finally nontypable H. influenzae not only lives on the mucosal surface but also clearly has been demonstrated to enter epithelial cells and remain viable in intracellular and intercellular locations in the human upper respiratory tract. These areas of investigation have important implications in understanding the pathogenesis of OM. Elucidating mechanisms of pathogenesis will be important in guiding development of novel ways to prevent OM.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0891-3668
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S9-15; discussion S15-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Bacterial otitis media: pathogenetic considerations.
pubmed:affiliation
Department of Medicine, State University of New York at Buffalo, Department of Veterans Affairs Western New York Healthcare System, 14215, USA. murphyt@acsu.buffalo.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review