Linked Life Data

10820287

Source:http://linkedlifedata.com/resource/pubmed/id/10820287

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2000-6-21
pubmed:abstractText
Chemokines direct leukocyte recruitment into sites of tissue inflammation and may facilitate recruitment of leukocytes into allografts following transplantation. Although the expression of chemokines during rejection of MHC-disparate allografts has been examined, chemokine expression in MHC-matched/multiple minor histocompatibility Ag-disparate allografts has not been tested. The intraallograft RNA expression of several C-X-C and C-C chemokines was tested during rejection of full thickness skin grafts from B10. D2 donors on control Ig-, anti-CD4 mAb-, and anti-CD8 mAb-treated BALB/c recipients. In all recipients, two patterns of intragraft chemokine expression were observed during rejection of these grafts: 1) macrophage-inflammatory protein-1alpha, macrophage-inflammatory protein-1beta, GRO-alpha (KC), JE, and IFN-gamma-inducible protein (IP-10) were expressed at equivalent levels in allo- and isografts for 2-4 days posttransplant and then returned to low or undetectable levels; and 2) IP-10 and monokine induced by IFN-gamma (Mig) were expressed in the allografts 3 days before rejection was completed, suggesting a possible role in recruiting primed T cells into the allograft. Three days before completion of rejection, intraallograft IP-10 protein was restricted to the epidermis, whereas Mig was located in the lower dermis and associated with the intense infiltration of mononuclear cells. Treatment of B10.D2 recipients with rabbit antiserum to Mig, but not to IP-10, delayed rejection of the allografts 3-4 days. The results suggest that Mig mediates optimal recruitment of T cells into MHC-matched/multiple minor histocompatibility Ag-disparate allografts during rejection.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
164
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6027-33
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:10820287-Amino Acid Sequence, pubmed-meshheading:10820287-Animals, pubmed-meshheading:10820287-CD4-Positive T-Lymphocytes, pubmed-meshheading:10820287-CD8-Positive T-Lymphocytes, pubmed-meshheading:10820287-Chemokine CXCL10, pubmed-meshheading:10820287-Chemokine CXCL9, pubmed-meshheading:10820287-Chemokines, pubmed-meshheading:10820287-Chemokines, CXC, pubmed-meshheading:10820287-Female, pubmed-meshheading:10820287-Gene Expression Regulation, pubmed-meshheading:10820287-Graft Rejection, pubmed-meshheading:10820287-Histocompatibility Testing, pubmed-meshheading:10820287-Immune Sera, pubmed-meshheading:10820287-Injections, Intraperitoneal, pubmed-meshheading:10820287-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:10820287-Lymphocyte Depletion, pubmed-meshheading:10820287-Mice, pubmed-meshheading:10820287-Mice, Inbred BALB C, pubmed-meshheading:10820287-Mice, Inbred C57BL, pubmed-meshheading:10820287-Mice, Inbred DBA, pubmed-meshheading:10820287-Minor Histocompatibility Antigens, pubmed-meshheading:10820287-Molecular Sequence Data, pubmed-meshheading:10820287-RNA, pubmed-meshheading:10820287-Rabbits, pubmed-meshheading:10820287-Skin Transplantation, pubmed-meshheading:10820287-Transplantation, Homologous
pubmed:year
2000
pubmed:articleTitle
Intraallograft chemokine RNA and protein during rejection of MHC-matched/multiple minor histocompatibility-disparate skin grafts.
pubmed:affiliation
Departments of Urology and Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't