| pubmed-article:10820234 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:10820234 | lifeskim:mentions | umls-concept:C1710158 | lld:lifeskim |
| pubmed-article:10820234 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:10820234 | lifeskim:mentions | umls-concept:C0439185 | lld:lifeskim |
| pubmed-article:10820234 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:10820234 | pubmed:dateCreated | 2000-6-21 | lld:pubmed |
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| pubmed-article:10820234 | pubmed:abstractText | The VH4 genes expressed by both resting and in vivo-activated subepithelial (SE) B cells from human tonsils were studied. Resting SE B cells were subdivided according to the presence (IgDlow) or absence (IgM-only) of surface IgD. CD27 was abundant on activated SE B cells and low on resting IgM-only B cells. Resting IgDlow SE B cells could be subdivided into CD27low and CD27high cell fractions. Resting IgDlow SE B cells displayed VH4 genes with a substantial number of mutations (13/29 of the molecular clones were mutated), whereas 25/26 of the clones from resting IgM-only SE B cells were unmutated. Moreover, mutated VH4 genes were detected mainly within the CD27high cell fraction of the IgDlow SE B cells. Several identical unmutated VH4DJH sequences (11/32) were found in different molecular clones from resting IgM-only SE B cells, suggesting local cellular expansion. Both unmutated (14/25) and mutated (11/25) sequences were found in mu transcripts of activated SE B cells. Extensive mutation was observed in the gamma transcripts of activated SE B cells. Therefore, SE B cells are heterogeneous, being comprised of B cells with mutated Ig VH4 genes, that are Ag-experienced B cells, and a subset of B cells with unmutated VH4 genes that are either virgin cells or cells driven by Ags that did not induce or select for V gene mutations. | lld:pubmed |
| pubmed-article:10820234 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10820234 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10820234 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:10820234 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10820234 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10820234 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10820234 | pubmed:author | pubmed-author:ChiorazziNN | lld:pubmed |
| pubmed-article:10820234 | pubmed:author | pubmed-author:FerrariniMM | lld:pubmed |
| pubmed-article:10820234 | pubmed:author | pubmed-author:DongEE | lld:pubmed |
| pubmed-article:10820234 | pubmed:author | pubmed-author:MelioliGG | lld:pubmed |
| pubmed-article:10820234 | pubmed:author | pubmed-author:FogliMM | lld:pubmed |
| pubmed-article:10820234 | pubmed:author | pubmed-author:ZupoSS | lld:pubmed |
| pubmed-article:10820234 | pubmed:author | pubmed-author:MelagranaAA | lld:pubmed |
| pubmed-article:10820234 | pubmed:author | pubmed-author:LeanzaNN | lld:pubmed |
| pubmed-article:10820234 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10820234 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10820234 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:10820234 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10820234 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10820234 | pubmed:pagination | 5596-604 | lld:pubmed |
| pubmed-article:10820234 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10820234 | pubmed:meshHeading | pubmed-meshheading:10820234... | lld:pubmed |
| pubmed-article:10820234 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10820234 | pubmed:articleTitle | Heterogeneity of tonsillar subepithelial B lymphocytes, the splenic marginal zone equivalents. | lld:pubmed |
| pubmed-article:10820234 | pubmed:affiliation | Servizio di Immunologia Clinica and Servizio di Citometria Centro Biotechnologie Avanzate, Istituto Nazionale per la Ricerca sul Cancro, IST, Genova, Italy. mdono@hp380.ist.unige.it | lld:pubmed |
| pubmed-article:10820234 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10820234 | pubmed:publicationType | Comparative Study | lld:pubmed |
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