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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2000-5-31
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pubmed:abstractText |
We have verified the presence of line-1 retrotransposon (L1) in plasma DNA in 15/17 brain tumor (glioma) patients and in 6/6 healthy people by applying PCR amplification of part of the L1 5' end. The same samples were separately amplified for K-ras. Results suggested that L1 sequences are circulating throughout the body. We hypothesized the participation of transposable elements such as L1 in a putative DNA release mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0077-8923
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
906
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
129-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10818608-Adult,
pubmed-meshheading:10818608-Aged,
pubmed-meshheading:10818608-Base Sequence,
pubmed-meshheading:10818608-Brain Neoplasms,
pubmed-meshheading:10818608-DNA, Neoplasm,
pubmed-meshheading:10818608-DNA Primers,
pubmed-meshheading:10818608-Female,
pubmed-meshheading:10818608-Glioma,
pubmed-meshheading:10818608-Humans,
pubmed-meshheading:10818608-Long Interspersed Nucleotide Elements,
pubmed-meshheading:10818608-Male,
pubmed-meshheading:10818608-Middle Aged,
pubmed-meshheading:10818608-Polymerase Chain Reaction
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pubmed:year |
2000
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pubmed:articleTitle |
DNA release by line-1 (L1) retrotransposon. Could it be possible?
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pubmed:affiliation |
Divisão de Genética, Instituto Nacional de Câncer, Rio de Janeiro, Brazil. gbrown@inca.org.br
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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