Linked Life Data

10818282

Source:http://linkedlifedata.com/resource/pubmed/id/10818282

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-8-3
pubmed:abstractText
Studies investigating temperament traits in humans and their biological correlates have found high levels of novelty seeking (NS) linked with dopaminergic system changes, and particularly a deficit of dopamine transporter. Harm avoidance and reward dependence, on the other hand, appeared to be associated, respectively with serotonin and noradrenaline changes. In the present study, we have investigated the dopaminergic (DA), serotonergic (5-HT), and noradrenergic (NE) functions in healthy volunteers by challenging the monoamine systems with the DA agonist bromocriptine, the 5-HT agonist D-fenfluramine, and the NE agonist clonidine, respectively. Parallel to this investigation, we examined the temperament traits of our subjects by measuring NS, harm avoidance (HA) and reward dependence (RD) using the 'Three-dimensional Personality Questionnaire' (TPQ). The aims of the study were to see whether or not the monoamine functions were correlated with temperament traits. Bromocriptine challenge induced a significant GH increase and a significant suppression of PRL. D-fenfluramine test significantly increased PRL and cortisol plasma levels and Clonidine test induced a significant rise in GH values. NS scores showed a significant direct correlation with brom-stimulated GH values (r=0.426, P<0.05) and a significant inverse correlation with brom-inhibited PRL values (r=-0.498, P<0.01). HA scores correlated significantly with D-fen-stimulated PRL and CORT AUCs, (PRL: r=0.424, P<0.05; CORT: r=0. 595, P<0.005). RD scores correlated positively with clon-stimulated GH values (r=0.55; F=8.6; P<0.01) and negatively with brom-inhibited-PRL AUCs (r=-0.439, P<0.05). Our data support Cloninger theory concerning the biological correlates of temperamental traits, and evidence the link between the neuroendocrine responses to dynamic challenges and stable temperament features.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0306-4530
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
479-96
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:10818282-Adrenergic alpha-Agonists, pubmed-meshheading:10818282-Adult, pubmed-meshheading:10818282-Avoidance Learning, pubmed-meshheading:10818282-Bromocriptine, pubmed-meshheading:10818282-Clonidine, pubmed-meshheading:10818282-Dopamine, pubmed-meshheading:10818282-Dopamine Agonists, pubmed-meshheading:10818282-Exploratory Behavior, pubmed-meshheading:10818282-Fenfluramine, pubmed-meshheading:10818282-Human Growth Hormone, pubmed-meshheading:10818282-Humans, pubmed-meshheading:10818282-Hydrocortisone, pubmed-meshheading:10818282-Male, pubmed-meshheading:10818282-Neurosecretory Systems, pubmed-meshheading:10818282-Norepinephrine, pubmed-meshheading:10818282-Prolactin, pubmed-meshheading:10818282-Reward, pubmed-meshheading:10818282-Serotonin, pubmed-meshheading:10818282-Serotonin Receptor Agonists, pubmed-meshheading:10818282-Temperament
pubmed:year
2000
pubmed:articleTitle
Neuroendocrine correlates of temperamental traits in humans.
pubmed:affiliation
Centro Studi Farmacotossicodipendenze, SER.T., AUSL di Parma, Via Spalato 2, 43100, Parma, Italy. pharmbeh@tin.it
pubmed:publicationType
Journal Article